LSM1

From Wikipedia, the free encyclopedia

LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae)

Identifiers

LSM1; CASM; YJL124C

External IDs

OMIM: 607281 MGI: 1914457 HomoloGene: 40945

Gene ontology
Molecular Function:	• protein binding • RNA splicing factor activity, transesterification mechanism
Cellular Component:	• nucleus • ribonucleoprotein complex
Biological Process:	• mRNA processing • RNA splicing

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014462 (mRNA)
NP_055277 (protein)

XM_357867 (mRNA)
XP_357867 (protein)

Location

Chr 8: 38.14 - 38.15 Mb

Chr 8: 27.25 - 27.27 Mb

Pubmed search

[1]

[2]

LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae), also known as LSM1, is a human gene.^[1]

Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: LSM1 LSM1 homolog, U6 small nuclear RNA associated (S. cerevisiae).

[edit] Further reading

Shimizu Y, Sugiyama H, Fujii Y, et al. (1997). "Lineage- and differentiation stage-specific expression of LSM-1 (LPAP), a possible substrate for CD45, in human hematopoietic cells.". Am. J. Hematol. 54 (1): 1-11. PMID 8980254.
Schweinfest CW, Graber MW, Chapman JM, et al. (1997). "CaSm: an Sm-like protein that contributes to the transformed state in cancer cells.". Cancer Res. 57 (14): 2961-5. PMID 9230209.
Salgado-Garrido J, Bragado-Nilsson E, Kandels-Lewis S, Séraphin B (1999). "Sm and Sm-like proteins assemble in two related complexes of deep evolutionary origin.". EMBO J. 18 (12): 3451-62. doi:10.1093/emboj/18.12.3451. PMID 10369684.
Achsel T, Brahms H, Kastner B, et al. (1999). "A doughnut-shaped heteromer of human Sm-like proteins binds to the 3'-end of U6 snRNA, thereby facilitating U4/U6 duplex formation in vitro.". EMBO J. 18 (20): 5789-802. doi:10.1093/emboj/18.20.5789. PMID 10523320.
Friesen WJ, Dreyfuss G (2000). "Specific sequences of the Sm and Sm-like (Lsm) proteins mediate their interaction with the spinal muscular atrophy disease gene product (SMN).". J. Biol. Chem. 275 (34): 26370-5. doi:10.1074/jbc.M003299200. PMID 10851237.
Eystathioy T, Peebles CL, Hamel JC, et al. (2002). "Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm sera.". Arthritis Rheum. 46 (3): 726-34. doi:10.1002/art.10220. PMID 11920408.
Takahashi S, Suzuki S, Inaguma S, et al. (2002). "Down-regulation of Lsm1 is involved in human prostate cancer progression.". Br. J. Cancer 86 (6): 940-6. doi:10.1038/sj.bjc.6600163. PMID 11953827.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Ingelfinger D, Arndt-Jovin DJ, Lührmann R, Achsel T (2003). "The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic foci.". RNA 8 (12): 1489-501. PMID 12515382.
Lehner B, Semple JI, Brown SE, et al. (2004). "Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region.". Genomics 83 (1): 153-67. PMID 14667819.
Lehner B, Sanderson CM (2004). "A protein interaction framework for human mRNA degradation.". Genome Res. 14 (7): 1315-23. doi:10.1101/gr.2122004. PMID 15231747.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Wichroski MJ, Robb GB, Rana TM (2006). "Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies.". PLoS Pathog. 2 (5): e41. doi:10.1371/journal.ppat.0020041. PMID 16699599.
Chu CY, Rana TM (2006). "Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54.". PLoS Biol. 4 (7): e210. doi:10.1371/journal.pbio.0040210. PMID 16756390.
Streicher KL, Yang ZQ, Draghici S, Ethier SP (2007). "Transforming function of the LSM1 oncogene in human breast cancers with the 8p11-12 amplicon.". Oncogene 26 (14): 2104-14. doi:10.1038/sj.onc.1210002. PMID 17001308.