LRP6

From Wikipedia, the free encyclopedia

Low density lipoprotein receptor-related protein 6

Identifiers

LRP6; FLJ90062; FLJ90421

External IDs

OMIM: 603507 MGI: 1298218 HomoloGene: 1747

Gene ontology
Molecular Function:	• receptor activity • low-density lipoprotein receptor activity • protein binding
Cellular Component:	• membrane fraction • plasma membrane • integral to membrane
Biological Process:	• endocytosis • multicellular organismal development • anterior/posterior pattern formation • gastrulation (sensu Mammalia) • Wnt receptor signaling pathway • negative regulation of Wnt receptor signaling pathway • embryonic forelimb morphogenesis • embryonic hindlimb morphogenesis • cell migration involved in gastrulation • embryonic digit morphogenesis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002336 (mRNA)
NP_002327 (protein)

NM_008514 (mRNA)
NP_032540 (protein)

Location

Chr 12: 12.16 - 12.31 Mb

Chr 6: 134.42 - 134.51 Mb

Pubmed search

[1]

[2]

Low density lipoprotein receptor-related protein 6, also known as LRP6, is a human gene.^[1]

[edit] References

^ Entrez Gene: LRP6 low density lipoprotein receptor-related protein 6.

[edit] Further reading

He X, Semenov M, Tamai K, Zeng X (2004). "LDL receptor-related proteins 5 and 6 in Wnt/beta-catenin signaling: arrows point the way.". Development 131 (8): 1663–77. doi:10.1242/dev.01117. PMID 15084453.
Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807–28. PMID 8889549.
Brown SD, Twells RC, Hey PJ, et al. (1998). "Isolation and characterization of LRP6, a novel member of the low density lipoprotein receptor gene family.". Biochem. Biophys. Res. Commun. 248 (3): 879–88. doi:10.1006/bbrc.1998.9061. PMID 9704021.
Baens M, Wlodarska I, Corveleyn A, et al. (1999). "A physical, transcript, and deletion map of chromosome region 12p12.3 flanked by ETV6 and CDKN1B: hypermethylation of the LRP6 CpG island in two leukemia patients with hemizygous del(12p).". Genomics 56 (1): 40–50. doi:10.1006/geno.1998.5685. PMID 10036184.
Tamai K, Semenov M, Kato Y, et al. (2000). "LDL-receptor-related proteins in Wnt signal transduction.". Nature 407 (6803): 530–5. doi:10.1038/35035117. PMID 11029007.
Mao B, Wu W, Li Y, et al. (2001). "LDL-receptor-related protein 6 is a receptor for Dickkopf proteins.". Nature 411 (6835): 321–5. doi:10.1038/35077108. PMID 11357136.
Semënov MV, Tamai K, Brott BK, et al. (2001). "Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6.". Curr. Biol. 11 (12): 951–61. PMID 11448771.
Li L, Mao J, Sun L, et al. (2002). "Second cysteine-rich domain of Dickkopf-2 activates canonical Wnt signaling pathway via LRP-6 independently of dishevelled.". J. Biol. Chem. 277 (8): 5977–81. doi:10.1074/jbc.M111131200. PMID 11742004.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Caricasole A, Ferraro T, Iacovelli L, et al. (2003). "Functional characterization of WNT7A signaling in PC12 cells: interaction with A FZD5 x LRP6 receptor complex and modulation by Dickkopf proteins.". J. Biol. Chem. 278 (39): 37024–31. doi:10.1074/jbc.M300191200. PMID 12857724.
Liu G, Bafico A, Harris VK, Aaronson SA (2003). "A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor.". Mol. Cell. Biol. 23 (16): 5825–35. PMID 12897152.
Zilberberg A, Yaniv A, Gazit A (2004). "The low density lipoprotein receptor-1, LRP1, interacts with the human frizzled-1 (HFz1) and down-regulates the canonical Wnt signaling pathway.". J. Biol. Chem. 279 (17): 17535–42. doi:10.1074/jbc.M311292200. PMID 14739301.
Wang X, Adhikari N, Li Q, Hall JL (2005). "LDL receptor-related protein LRP6 regulates proliferation and survival through the Wnt cascade in vascular smooth muscle cells.". Am. J. Physiol. Heart Circ. Physiol. 287 (6): H2376–83. doi:10.1152/ajpheart.01173.2003. PMID 15271658.
Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMID 15342556.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Li Y, Lu W, He X, et al. (2005). "LRP6 expression promotes cancer cell proliferation and tumorigenesis by altering beta-catenin subcellular distribution.". Oncogene 23 (56): 9129–35. doi:10.1038/sj.onc.1208123. PMID 15516984.
Semënov M, Tamai K, He X (2005). "SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitor.". J. Biol. Chem. 280 (29): 26770–5. doi:10.1074/jbc.M504308200. PMID 15908424.
Li Y, Chen J, Lu W, et al. (2006). "Mesd binds to mature LDL-receptor-related protein-6 and antagonizes ligand binding.". J. Cell. Sci. 118 (Pt 22): 5305–14. doi:10.1242/jcs.02651. PMID 16263759.
Mi K, Dolan PJ, Johnson GV (2006). "The low density lipoprotein receptor-related protein 6 interacts with glycogen synthase kinase 3 and attenuates activity.". J. Biol. Chem. 281 (8): 4787–94. doi:10.1074/jbc.M508657200. PMID 16365045.