LRP2

From Wikipedia, the free encyclopedia

Low density lipoprotein-related protein 2

Identifiers

LRP2; gp330

External IDs

OMIM: 600073 MGI: 95794 HomoloGene: 20952

Gene ontology
Molecular Function:	• receptor activity • calcium ion binding • protein binding
Cellular Component:	• lysosome • coated pit • membrane • integral to membrane
Biological Process:	• protein amino acid glycosylation • lipid metabolic process • receptor-mediated endocytosis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_004525 (mRNA)
NP_004516 (protein)

XM_130308 (mRNA)
XP_130308 (protein)

Location

Chr 2: 169.69 - 169.93 Mb

Chr 2: 69.23 - 69.39 Mb

Pubmed search

[1]

[2]

Low density lipoprotein-related protein 2, also known as LRP2, is a protein forming a receptor found in the plasma membrane of human cells involved in receptor-mediated endocytosis.

Lipoprotein receptor-related protein-2 (LRP2), also called glycoprotein 330 or megalin (Farquhar, 1995), is part of the Heymann nephritis antigenic complex with RAP (LRPAP1; MIM 104225) (Farquhar et al., 1995) and is a member of a family of receptors with structural similarities to the low density lipoprotein receptor (LDLR; MIM 606945).[supplied by OMIM]^[1]

[edit] References

^ Entrez Gene: LRP2 low density lipoprotein-related protein 2.

[edit] Further reading

Farquhar MG, Saito A, Kerjaschki D, Orlando RA (1995). "The Heymann nephritis antigenic complex: megalin (gp330) and RAP.". J. Am. Soc. Nephrol. 6 (1): 35–47. PMID 7579068.
Farquhar MG (1995). "The unfolding story of megalin (gp330): now recognized as a drug receptor.". J. Clin. Invest. 96 (3): 1184. PMID 7657789.
Christensen EI, Birn H (2002). "Megalin and cubilin: multifunctional endocytic receptors.". Nat. Rev. Mol. Cell Biol. 3 (4): 256–66. doi:10.1038/nrm778. PMID 11994745.
Saito A, Takeda T, Hama H, et al. (2006). "Role of megalin, a proximal tubular endocytic receptor, in the pathogenesis of diabetic and metabolic syndrome-related nephropathies: protein metabolic overload hypothesis.". Nephrology (Carlton, Vic.) 10 Suppl: S26–31. doi:10.1111/j.1440-1797.2005.00453.x. PMID 16174284.
Fisher CE, Howie SE (2006). "The role of megalin (LRP-2/Gp330) during development.". Dev. Biol. 296 (2): 279–97. doi:10.1016/j.ydbio.2006.06.007. PMID 16828734.
Christensen EI, Gliemann J, Moestrup SK (1992). "Renal tubule gp330 is a calcium binding receptor for endocytic uptake of protein.". J. Histochem. Cytochem. 40 (10): 1481–90. PMID 1382088.
Raychowdhury R, Niles JL, McCluskey RT, Smith JA (1989). "Autoimmune target in Heymann nephritis is a glycoprotein with homology to the LDL receptor.". Science 244 (4909): 1163–5. PMID 2786251.
Orlando RA, Farquhar MG (1994). "Functional domains of the receptor-associated protein (RAP).". Proc. Natl. Acad. Sci. U.S.A. 91 (8): 3161–5. PMID 7512726.
Kounnas MZ, Chappell DA, Strickland DK, Argraves WS (1993). "Glycoprotein 330, a member of the low density lipoprotein receptor family, binds lipoprotein lipase in vitro.". J. Biol. Chem. 268 (19): 14176–81. PMID 7686151.
Kounnas MZ, Loukinova EB, Stefansson S, et al. (1995). "Identification of glycoprotein 330 as an endocytic receptor for apolipoprotein J/clusterin.". J. Biol. Chem. 270 (22): 13070–5. PMID 7768901.
Korenberg JR, Argraves KM, Chen XN, et al. (1994). "Chromosomal localization of human genes for the LDL receptor family member glycoprotein 330 (LRP2) and its associated protein RAP (LRPAP1).". Genomics 22 (1): 88–93. doi:10.1006/geno.1994.1348. PMID 7959795.
Lundgren S, Hjälm G, Hellman P, et al. (1994). "A protein involved in calcium sensing of the human parathyroid and placental cytotrophoblast cells belongs to the LDL-receptor protein superfamily.". Exp. Cell Res. 212 (2): 344–50. PMID 8187828.
Moestrup SK, Nielsen S, Andreasen P, et al. (1993). "Epithelial glycoprotein-330 mediates endocytosis of plasminogen activator-plasminogen activator inhibitor type-1 complexes.". J. Biol. Chem. 268 (22): 16564–70. PMID 8344937.
Hjälm G, Murray E, Crumley G, et al. (1996). "Cloning and sequencing of human gp330, a Ca(2+)-binding receptor with potential intracellular signaling properties.". Eur. J. Biochem. 239 (1): 132–7. PMID 8706697.
Willnow TE, Hilpert J, Armstrong SA, et al. (1996). "Defective forebrain development in mice lacking gp330/megalin.". Proc. Natl. Acad. Sci. U.S.A. 93 (16): 8460–4. PMID 8710893.
Cui S, Verroust PJ, Moestrup SK, Christensen EI (1996). "Megalin/gp330 mediates uptake of albumin in renal proximal tubule.". Am. J. Physiol. 271 (4 Pt 2): F900–7. PMID 8898021.
Lundgren S, Carling T, Hjälm G, et al. (1997). "Tissue distribution of human gp330/megalin, a putative Ca(2+)-sensing protein.". J. Histochem. Cytochem. 45 (3): 383–92. PMID 9071320.
Birn H, Verroust PJ, Nexo E, et al. (1997). "Characterization of an epithelial approximately 460-kDa protein that facilitates endocytosis of intrinsic factor-vitamin B12 and binds receptor-associated protein.". J. Biol. Chem. 272 (42): 26497–504. PMID 9334227.