LRP1

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Low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)
PDB rendering based on 1cr8.
Available structures: 1cr8, 1d2l, 1j8e, 2fyj, 2fyl
Identifiers
Symbol(s) LRP1; LRP; A2MR; APOER; APR; CD91; FLJ16451; MGC88725; TGFBR5
External IDs OMIM: 107770 MGI: 96828 HomoloGene: 1744
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 4035 16971
Ensembl ENSG00000123384 ENSMUSG00000040249
Uniprot Q07954 Q3U454
Refseq NM_002332 (mRNA)
NP_002323 (protein)		 NM_008512 (mRNA)
NP_032538 (protein)
Location Chr 12: 55.81 - 55.89 Mb Chr 10: 126.94 - 127.02 Mb
Pubmed search [1] [2]

Low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor), also known as LRP1 or CD91, is a protein forming a receptor found in the plasma membrane of human cells involved in receptor-mediated endocytosis.

Contents

[edit] LRP1 and Alzheimer's disease

Neurons require cholesterol to function. Cholesterol is imported into the neuron by the apolipoprotein apoE4 via LRP1 receptors on the cell surface. It thought that a causal factor in Alzheimer's is the malfunction of this process which damages neurons by starving them of cholesterol.[1]


[edit] References

  1. ^ Liu Q, Zerbinatti CV, Zhang J, Hoe HS, Wang B, Cole SL, Herz J, Muglia L, Bu G. (2007) Amyloid precursor protein regulates brain apolipoprotein E and cholesterol metabolism through lipoprotein receptor LRP1. Neuron 56(1):66-78. PMID 17920016

[edit] See also

[edit] Further reading

  • Li Z, Dai J, Zheng H, et al. (2002). "An integrated view of the roles and mechanisms of heat shock protein gp96-peptide complex in eliciting immune response.". Front. Biosci. 7: d731–51. PMID 11861214. 
  • van der Geer P (2002). "Phosphorylation of LRP1: regulation of transport and signal transduction.". Trends Cardiovasc. Med. 12 (4): 160–5. PMID 12069755. 
  • May P, Herz J (2004). "LDL receptor-related proteins in neurodevelopment.". Traffic 4 (5): 291–301. PMID 12713657. 
  • Llorente-Cortés V, Badimon L (2005). "LDL receptor-related protein and the vascular wall: implications for atherothrombosis.". Arterioscler. Thromb. Vasc. Biol. 25 (3): 497–504. doi:10.1161/01.ATV.0000154280.62072.fd. PMID 15705932. 
  • Huang SS, Huang JS (2005). "TGF-beta control of cell proliferation.". J. Cell. Biochem. 96 (3): 447–62. doi:10.1002/jcb.20558. PMID 16088940. 
  • Lillis AP, Mikhailenko I, Strickland DK (2005). "Beyond endocytosis: LRP function in cell migration, proliferation and vascular permeability.". J. Thromb. Haemost. 3 (8): 1884–93. doi:10.1111/j.1538-7836.2005.01371.x. PMID 16102056. 

[edit] External links

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v • d • e
Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1-50
CD1 (a-c, 1A, 1D, 1E) - CD2 - CD3 (γ, δ, ε) - CD4 - CD5 - CD6 - CD7 - CD8 (a) - CD9 - CD10 - CD11 (a, b, c) - CD13 - CD14 - CD15 - CD16 (A, B) - CD18 - CD19 - CD20 - CD21 - CD22 - CD23 - CD24 - CD25 - CD26 - CD27 - CD28 - CD29 - CD30 - CD31 - CD32 (A, B) - CD33 - CD34 - CD35 - CD36 - CD37 - CD38 - CD39 - CD40 - CD41- CD42 (a, b, c, d) - CD43 - CD44 - CD45 - CD46 - CD47 - CD48 - CD49 (a, b, c, d, e, f) - CD50
51-100
CD51 - CD52 - CD53 - CD54 - CD55 - CD56 - CD57- CD58 - CD59 - CD61 - CD62 (E, L, P) - CD63 - CD64 - CD66 (a, b, c, d, e, f) - CD68 - CD69 - CD70 - CD71 - CD72 - CD73 - CD74 - CD79 (a, b) - CD80 - CD81 - CD82 - CD83 - CD84 - CD85 (a, d, e, h, j, k) - CD86 - CD87 - CD88 - CD89 - CD90 - CD91- CD92 - CD93 - CD94 - CD95 - CD97 - CD98 - CD99 - CD100
101-150
CD101 - CD102 - CD103 - CD104 - CD105 - CD106 - CD107 (a, b) - CD108 - CD109 - CD110 - CD111 - CD112 - CD113 - CD114 - CD115 - CD116 - CD117 - CD118 - CD119 - CD120 (a, b) - CD121 (a, b) - CD122 - CD123 - CD124 - CD125 - CD126 - CD127 - CD129 - CD130 - CD131 - CD132 - CD133 - CD134 - CD135 - CD136 - CD137 - CD138 - CD140b - CD141 - CD142 - CD143 - CD144 - CD146 - CD147 - CD148 - CD150
151-200
CD151 - CD152 - CD153 - CD154 - CD155 - CD156 (a, b, c) - CD157 - CD158 (a, d, e, i, k) - CD159 (a, c) - CD160 - CD161 - CD162 - CD163 - CD164 - CD166 - CD167 (a, b) - CD168 - CD169 - CD170 - CD171 - CD172 (a, b, g) - CD174 - CD177 - CD178 - CD179 (a, b) - CD181 - CD182 - CD183 - CD184 - CD185 - CD186 - CD191 - CD192 - CD193 - CD194 - CD195 - CD196 - CD197 - CDw198 - CDw199 - CD200
201-250
CD201 - CD202b - CD204 - CD205 - CD206 - CD207 - CD208 - CD209 - CDw210 (a, b) - CD212 - CD213a (1, 2) - CD217 - CD218 (a, b) - CD220 - CD221 - CD222 - CD223 - CD224 - CD225 - CD226 - CD227 - CD228 - CD229 - CD230 - CD233 - CD234 - CD235 (a, b) - CD236 - CD238 - CD239 - CD240CE - CD241 - CD243 - CD244 - CD246 - CD247- CD248 - CD249
251-300
301-350
Languages