LRP1B

From Wikipedia, the free encyclopedia

Low density lipoprotein-related protein 1B (deleted in tumors)

Identifiers

LRP1B; LRP-DIT; LRPDIT

External IDs

OMIM: 608766 MGI: 2151136 HomoloGene: 56810

Gene ontology
Molecular Function:	• receptor activity • low-density lipoprotein receptor activity • calcium ion binding
Cellular Component:	• membrane • integral to membrane
Biological Process:	• receptor-mediated endocytosis • protein transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_018557 (mRNA)
NP_061027 (protein)

XM_985447 (mRNA)
XP_990541 (protein)

Location

Chr 2: 140.71 - 142.6 Mb

n/a

Pubmed search

[1]

[2]

Low density lipoprotein-related protein 1B (deleted in tumors), also known as LRP1B, is a human gene.^[1]

LRP1B belongs to the low density lipoprotein (LDL) receptor gene family. These receptors play a wide variety of roles in normal cell function and development due to their interactions with multiple ligands (Liu et al., 2001).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: LRP1B low density lipoprotein-related protein 1B (deleted in tumors).

[edit] Further reading

Liu CX, Musco S, Lisitsina NM, et al. (2000). "LRP-DIT, a putative endocytic receptor gene, is frequently inactivated in non-small cell lung cancer cell lines.". Cancer Res. 60 (7): 1961–7. PMID 10766186.
Liu CX, Musco S, Lisitsina NM, et al. (2001). "Genomic organization of a new candidate tumor suppressor gene, LRP1B.". Genomics 69 (2): 271–4. doi:10.1006/geno.2000.6331. PMID 11031110.
Liu CX, Li Y, Obermoeller-McCormick LM, et al. (2001). "The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein.". J. Biol. Chem. 276 (31): 28889–96. doi:10.1074/jbc.M102727200. PMID 11384978.
Langbein S, Szakacs O, Wilhelm M, et al. (2002). "Alteration of the LRP1B gene region is associated with high grade of urothelial cancer.". Lab. Invest. 82 (5): 639–43. PMID 12004004.
Li Y, Knisely JM, Lu W, et al. (2003). "Low density lipoprotein (LDL) receptor-related protein 1B impairs urokinase receptor regeneration on the cell surface and inhibits cell migration.". J. Biol. Chem. 277 (44): 42366–71. doi:10.1074/jbc.M207705200. PMID 12194987.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Cam JA, Zerbinatti CV, Knisely JM, et al. (2004). "The low density lipoprotein receptor-related protein 1B retains beta-amyloid precursor protein at the cell surface and reduces amyloid-beta peptide production.". J. Biol. Chem. 279 (28): 29639–46. doi:10.1074/jbc.M313893200. PMID 15126508.
Tanaga K, Bujo H, Zhu Y, et al. (2005). "LRP1B attenuates the migration of smooth muscle cells by reducing membrane localization of urokinase and PDGF receptors.". Arterioscler. Thromb. Vasc. Biol. 24 (8): 1422–8. doi:10.1161/01.ATV.0000133607.80554.09. PMID 15166012.
Sonoda I, Imoto I, Inoue J, et al. (2004). "Frequent silencing of low density lipoprotein receptor-related protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in esophageal squamous cell carcinoma.". Cancer Res. 64 (11): 3741–7. doi:10.1158/0008-5472.CAN-04-0172. PMID 15172977.
Li Y, Lu W, Bu G (2005). "Striking differences of LDL receptor-related protein 1B expression in mouse and human.". Biochem. Biophys. Res. Commun. 333 (3): 868–73. doi:10.1016/j.bbrc.2005.05.170. PMID 15963947.
Pastrana DV, Hanson AJ, Knisely J, et al. (2006). "LRP 1 B functions as a receptor for Pseudomonas exotoxin.". Biochim. Biophys. Acta 1741 (3): 234–9. doi:10.1016/j.bbadis.2005.06.007. PMID 16095885.
Nakagawa T, Pimkhaokham A, Suzuki E, et al. (2006). "Genetic or epigenetic silencing of low density lipoprotein receptor-related protein 1B expression in oral squamous cell carcinoma.". Cancer Sci. 97 (10): 1070–4. doi:10.1111/j.1349-7006.2006.00283.x. PMID 16918994.
Liu CX, Ranganathan S, Robinson S, Strickland DK (2007). "gamma-Secretase-mediated release of the low density lipoprotein receptor-related protein 1B intracellular domain suppresses anchorage-independent growth of neuroglioma cells.". J. Biol. Chem. 282 (10): 7504–11. doi:10.1074/jbc.M608088200. PMID 17227771.