LRDD

From Wikipedia, the free encyclopedia

Leucine-rich repeats and death domain containing

PDB rendering based on 2of5.

Available structures: 2of5

Identifiers

Symbol(s)

LRDD; DKFZp434D229; MGC16925; PIDD

External IDs

OMIM: 605247 MGI: 1889507 HomoloGene: 11220

Gene ontology
Molecular Function:	• death receptor binding • protein binding
Cellular Component:	• nucleus
Biological Process:	• apoptosis • signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_018494 (mRNA)
NP_060964 (protein)

NM_022654 (mRNA)
NP_073145 (protein)

Location

Chr 11: 0.79 - 0.79 Mb

Chr 7: 141.29 - 141.3 Mb

Pubmed search

[1]

[2]

Leucine-rich repeats and death domain containing, also known as LRDD, is a human gene.^[1]

The protein encoded by this gene contains a leucine-rich repeat and a death domain. This protein has been shown to interact with other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor p53 and to induce cell apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been reported.^[1]

[edit] References

^ ^a ^b Entrez Gene: LRDD leucine-rich repeats and death domain containing.

[edit] Further reading

Telliez JB, Bean KM, Lin LL (2000). "LRDD, a novel leucine rich repeat and death domain containing protein.". Biochim. Biophys. Acta 1478 (2): 280–8. PMID 10825539.
Lin Y, Ma W, Benchimol S (2000). "Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis.". Nat. Genet. 26 (1): 122–7. doi:10.1038/79102. PMID 10973264.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Tinel A, Tschopp J (2004). "The PIDDosome, a protein complex implicated in activation of caspase-2 in response to genotoxic stress.". Science 304 (5672): 843–6. doi:10.1126/science.1095432. PMID 15073321.
Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Janssens S, Tinel A, Lippens S, Tschopp J (2006). "PIDD mediates NF-kappaB activation in response to DNA damage.". Cell 123 (6): 1079–92. doi:10.1016/j.cell.2005.09.036. PMID 16360037.
Vakifahmetoglu H, Olsson M, Orrenius S, Zhivotovsky B (2006). "Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage.". Oncogene 25 (41): 5683–92. doi:10.1038/sj.onc.1209569. PMID 16652156.
Pick R, Badura S, Bösser S, Zörnig M (2006). "Upon intracellular processing, the C-terminal death domain-containing fragment of the p53-inducible PIDD/LRDD protein translocates to the nucleoli and interacts with nucleolin.". Biochem. Biophys. Res. Commun. 349 (4): 1329–38. doi:10.1016/j.bbrc.2006.08.176. PMID 16982033.
Tinel A, Janssens S, Lippens S, et al. (2007). "Autoproteolysis of PIDD marks the bifurcation between pro-death caspase-2 and pro-survival NF-kappaB pathway.". EMBO J. 26 (1): 197–208. doi:10.1038/sj.emboj.7601473. PMID 17159900.
Park HH, Wu H (2007). "Crystallization and preliminary X-ray crystallographic studies of the oligomeric death-domain complex between PIDD and RAIDD.". Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 63 (Pt 3): 229–32. doi:10.1107/S1744309107007889. PMID 17329820.
Bradley G, Tremblay S, Irish J, et al. (2007). "The expression of p53-induced protein with death domain (Pidd) and apoptosis in oral squamous cell carcinoma.". Br. J. Cancer 96 (9): 1425–32. doi:10.1038/sj.bjc.6603745. PMID 17437012.