LOXL3

From Wikipedia, the free encyclopedia

Lysyl oxidase-like 3

Identifiers

External IDs

OMIM: 607163 MGI: 1337004 HomoloGene: 56591

Gene ontology
Molecular Function:	• protein-lysine 6-oxidase activity • scavenger receptor activity • copper ion binding • oxidoreductase activity • metal ion binding
Cellular Component:	• extracellular region • membrane
Biological Process:	• biological_process

Orthologs

Human

Mouse

Refseq

NM_032603 (mRNA)
NP_115992 (protein)

XM_622564 (mRNA)
XP_622564 (protein)

Location

Chr 2: 74.61 - 74.63 Mb

Chr 6: 83 - 83.02 Mb

Pubmed search

[1]

[2]

Lysyl oxidase-like 3, also known as LOXL3, is a human gene.^[1]

This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Alternatively spliced transcript variants of this gene have been reported but their full-length nature has not been determined.^[1]

[edit] References

^ ^a ^b Entrez Gene: LOXL3 lysyl oxidase-like 3.

[edit] Further reading

Molnar J, Fong KS, He QP, et al. (2003). "Structural and functional diversity of lysyl oxidase and the LOX-like proteins.". Biochim. Biophys. Acta 1647 (1-2): 220-4. PMID 12686136.
Csiszar K (2001). "Lysyl oxidases: a novel multifunctional amine oxidase family.". Prog. Nucleic Acid Res. Mol. Biol. 70: 1-32. PMID 11642359.
Akagawa H, Narita A, Yamada H, et al. (2007). "Systematic screening of lysyl oxidase-like (LOXL) family genes demonstrates that LOXL2 is a susceptibility gene to intracranial aneurysms.". Hum. Genet. 121 (3-4): 377-87. doi:10.1007/s00439-007-0333-3. PMID 17287949.
Lee JE, Kim Y (2007). "A tissue-specific variant of the human lysyl oxidase-like protein 3 (LOXL3) functions as an amine oxidase with substrate specificity.". J. Biol. Chem. 281 (49): 37282-90. doi:10.1074/jbc.M600977200. PMID 17018530.
Peinado H, Del Carmen Iglesias-de la Cruz M, Olmeda D, et al. (2006). "A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression.". EMBO J. 24 (19): 3446-58. doi:10.1038/sj.emboj.7600781. PMID 16096638.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Jourdan-Le Saux C, Tomsche A, Ujfalusi A, et al. (2001). "Central nervous system, uterus, heart, and leukocyte expression of the LOXL3 gene, encoding a novel lysyl oxidase-like protein.". Genomics 74 (2): 211-8. doi:10.1006/geno.2001.6545. PMID 11386757.
Huang Y, Dai J, Tang R, et al. (2001). "Cloning and characterization of a human lysyl oxidase-like 3 gene (hLOXL3).". Matrix Biol. 20 (2): 153-7. PMID 11334717.
Mäki JM, Kivirikko KI (2001). "Cloning and characterization of a fourth human lysyl oxidase isoenzyme.". Biochem. J. 355 (Pt 2): 381-7. PMID 11284725.