LOXL2

From Wikipedia, the free encyclopedia

Lysyl oxidase-like 2

Identifiers

LOXL2; LOR2; WS9-14

External IDs

OMIM: 606663 MGI: 2137913 HomoloGene: 1742

Gene ontology
Molecular Function:	• protein-lysine 6-oxidase activity • scavenger receptor activity • copper ion binding • electron carrier activity • metal ion binding
Cellular Component:	• extracellular space • membrane
Biological Process:	• protein modification process • cell adhesion • aging

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002318 (mRNA)
NP_002309 (protein)

XM_985144 (mRNA)
XP_990238 (protein)

Location

Chr 8: 23.21 - 23.28 Mb

Chr 14: 68.34 - 68.43 Mb

Pubmed search

[1]

[2]

Lysyl oxidase-like 2, also known as LOXL2, is a human gene.^[1]

This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.^[1]

[edit] References

^ ^a ^b Entrez Gene: LOXL2 lysyl oxidase-like 2.

[edit] Further reading

Csiszar K (2001). "Lysyl oxidases: a novel multifunctional amine oxidase family.". Prog. Nucleic Acid Res. Mol. Biol. 70: 1-32. PMID 11642359.
Molnar J, Fong KS, He QP, et al. (2003). "Structural and functional diversity of lysyl oxidase and the LOX-like proteins.". Biochim. Biophys. Acta 1647 (1-2): 220-4. PMID 12686136.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298.
Saito H, Papaconstantinou J, Sato H, Goldstein S (1997). "Regulation of a novel gene encoding a lysyl oxidase-related protein in cellular adhesion and senescence.". J. Biol. Chem. 272 (13): 8157-60. PMID 9079631.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149.
Jourdan-Le Saux C, Le Saux O, Donlon T, et al. (1998). "The human lysyl oxidase-related gene (LOXL2) maps between markers D8S280 and D8S278 on chromosome 8p21.2-p21.3.". Genomics 51 (2): 305-7. doi:10.1006/geno.1998.5356. PMID 9722957.
Jourdan-Le Saux C, Tronecker H, Bogic L, et al. (1999). "The LOXL2 gene encodes a new lysyl oxidase-like protein and is expressed at high levels in reproductive tissues.". J. Biol. Chem. 274 (18): 12939-44. PMID 10212285.
Hein S, Yamamoto SY, Okazaki K, et al. (2001). "Lysyl oxidases: expression in the fetal membranes and placenta.". Placenta 22 (1): 49-57. doi:10.1053/plac.2000.0580. PMID 11162352.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Akiri G, Sabo E, Dafni H, et al. (2003). "Lysyl oxidase-related protein-1 promotes tumor fibrosis and tumor progression in vivo.". Cancer Res. 63 (7): 1657-66. PMID 12670920.
Rost T, Pyritz V, Rathcke IO, et al. (2003). "Reduction of LOX- and LOXL2-mRNA expression in head and neck squamous cell carcinomas.". Anticancer Res. 23 (2B): 1565-73. PMID 12820424.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Vadasz Z, Kessler O, Akiri G, et al. (2005). "Abnormal deposition of collagen around hepatocytes in Wilson's disease is associated with hepatocyte specific expression of lysyl oxidase and lysyl oxidase like protein-2.". J. Hepatol. 43 (3): 499-507. doi:10.1016/j.jhep.2005.02.052. PMID 16023247.
Peinado H, Del Carmen Iglesias-de la Cruz M, Olmeda D, et al. (2006). "A molecular role for lysyl oxidase-like 2 enzyme in snail regulation and tumor progression.". EMBO J. 24 (19): 3446-58. doi:10.1038/sj.emboj.7600781. PMID 16096638.
Akagawa H, Narita A, Yamada H, et al. (2007). "Systematic screening of lysyl oxidase-like (LOXL) family genes demonstrates that LOXL2 is a susceptibility gene to intracranial aneurysms.". Hum. Genet. 121 (3-4): 377-87. doi:10.1007/s00439-007-0333-3. PMID 17287949.