LOXL1

From Wikipedia, the free encyclopedia

Lysyl oxidase-like 1

Identifiers

LOXL1; LOL; LOXL

External IDs

OMIM: 153456 MGI: 106096 HomoloGene: 4074

Gene ontology
Molecular Function:	• protein-lysine 6-oxidase activity • copper ion binding • oxidoreductase activity • metal ion binding
Cellular Component:	• extracellular region
Biological Process:	• electron transport • protein amino acid deamination

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

XM_001133864 (mRNA)
XP_001133864 (protein)

NM_010729 (mRNA)
NP_034859 (protein)

Location

Chr 15: 72.01 - 72.03 Mb

Chr 9: 58.09 - 58.11 Mb

Pubmed search

[1]

[2]

Lysyl oxidase-like 1, also known as LOXL1, is a human gene.^[1]

This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.^[1]

[edit] References

^ ^a ^b Entrez Gene: LOXL1 lysyl oxidase-like 1.

[edit] Further reading

Csiszar K (2001). "Lysyl oxidases: a novel multifunctional amine oxidase family.". Prog. Nucleic Acid Res. Mol. Biol. 70: 1–32. PMID 11642359.
Kagan HM, Li W (2003). "Lysyl oxidase: properties, specificity, and biological roles inside and outside of the cell.". J. Cell. Biochem. 88 (4): 660–72. doi:10.1002/jcb.10413. PMID 12577300.
Molnar J, Fong KS, He QP, et al. (2003). "Structural and functional diversity of lysyl oxidase and the LOX-like proteins.". Biochim. Biophys. Acta 1647 (1-2): 220–4. PMID 12686136.
Kenyon K, Modi WS, Contente S, Friedman RM (1993). "A novel human cDNA with a predicted protein similar to lysyl oxidase maps to chromosome 15q24-q25.". J. Biol. Chem. 268 (25): 18435–7. PMID 7689553.
Kim Y, Boyd CD, Csiszar K (1995). "A new gene with sequence and structural similarity to the gene encoding human lysyl oxidase.". J. Biol. Chem. 270 (13): 7176–82. PMID 7706256.
Goy A, Gilles F, Remache Y, Zelenetz AD (2000). "Physical linkage of the lysyl oxidase-like (LOXL1) gene to the PML gene on human chromosome 15q22.". Cytogenet. Cell Genet. 88 (1-2): 22–4. PMID 10773658.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Jung ST, Kim MS, Seo JY, et al. (2004). "Purification of enzymatically active human lysyl oxidase and lysyl oxidase-like protein from Escherichia coli inclusion bodies.". Protein Expr. Purif. 31 (2): 240–6. PMID 14550642.
Liu X, Zhao Y, Gao J, et al. (2004). "Elastic fiber homeostasis requires lysyl oxidase-like 1 protein.". Nat. Genet. 36 (2): 178–82. doi:10.1038/ng1297. PMID 14745449.
Noblesse E, Cenizo V, Bouez C, et al. (2004). "Lysyl oxidase-like and lysyl oxidase are present in the dermis and epidermis of a skin equivalent and in human skin and are associated to elastic fibers.". J. Invest. Dermatol. 122 (3): 621–30. doi:10.1111/j.0022-202X.2004.22330.x. PMID 15086544.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Thomassin L, Werneck CC, Broekelmann TJ, et al. (2006). "The Pro-regions of lysyl oxidase and lysyl oxidase-like 1 are required for deposition onto elastic fibers.". J. Biol. Chem. 280 (52): 42848–55. doi:10.1074/jbc.M506832200. PMID 16251195.
Cenizo V, André V, Reymermier C, et al. (2007). "LOXL as a target to increase the elastin content in adult skin: a dill extract induces the LOXL gene expression.". Exp. Dermatol. 15 (8): 574–81. doi:10.1111/j.1600-0625.2006.00442.x. PMID 16842595.
Thorleifsson G, Magnusson KP, Sulem P, et al. (2007). "Common sequence variants in the LOXL1 gene confer susceptibility to exfoliation glaucoma.". Science 317 (5843): 1397–400. doi:10.1126/science.1146554. PMID 17690259.
Damji KF (2007). "Progress in understanding pseudoexfoliation syndrome and pseudoexfoliation-associated glaucoma.". Can. J. Ophthalmol. 42 (5): 657–8. doi:10.1139/i07-158. PMID 17891191.