Low density lipoprotein receptor-related protein 8

From Wikipedia, the free encyclopedia

Low density lipoprotein receptor-related protein 8, apolipoprotein e receptor

Identifiers

LRP8; APOER2; HSZ75190

External IDs

OMIM: 602600 MGI: 1340044 HomoloGene: 31250

Gene ontology
Molecular Function:	• receptor activity • transmembrane receptor activity • calcium ion binding • lipoprotein binding • apolipoprotein E receptor activity
Cellular Component:	• plasma membrane • membrane • integral to membrane
Biological Process:	• proteolysis • lipid metabolic process • endocytosis • signal transduction • cytokine and chemokine mediated signaling pathway • positive regulation of protein kinase activity

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001018054 (mRNA)
NP_001018064 (protein)

NM_001080926 (mRNA)
NP_001074395 (protein)

Location

Chr 1: 53.48 - 53.57 Mb

Chr 4: 107.3 - 107.37 Mb

Pubmed search

[1]

[2]

Low density lipoprotein receptor-related protein 8, apolipoprotein e receptor, also known as LRP8, is a human gene.^[1]

Low density lipoprotein receptor-related protein 8, or LRP8 (also Apolipoprotein E Receptor 2; ApoER2) is a member of the LDL receptor family that plays a role in endocytosis and signal transduction. Together with VLDLR it is able to bind reelin, leading to the phosphorylation of DAB1, which binds on its cytosolic tail.

This gene encodes an apolipoprotein E receptor, a member of the low density lipoprotein receptor (LDLR) family. Apolipoprotein E is a small lipophilic plasma protein and a component of lipoproteins such as chylomicron remnants, very low density lipoprotein (VLDL), and high density lipoprotein (HDL). The apolipoprotein E receptor is involved in cellular recognition and internalization of these lipoproteins. Alternative splicing generates multiple transcript variants encoding distinct isoforms for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor.

[edit] Further reading

Kim DH, Iijima H, Goto K, et al. (1996). "Human apolipoprotein E receptor 2. A novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain.". J. Biol. Chem. 271 (14): 8373–80. PMID 8626535.
Kim DH, Magoori K, Inoue TR, et al. (1997). "Exon/intron organization, chromosome localization, alternative splicing, and transcription units of the human apolipoprotein E receptor 2 gene.". J. Biol. Chem. 272 (13): 8498–504. PMID 9079678.
Clatworthy AE, Stockinger W, Christie RH, et al. (1999). "Expression and alternate splicing of apolipoprotein E receptor 2 in brain.". Neuroscience 90 (3): 903–11. PMID 10218790.
Sun XM, Soutar AK (1999). "Expression in vitro of alternatively spliced variants of the messenger RNA for human apolipoprotein E receptor-2 identified in human tissues by ribonuclease protection assays.". Eur. J. Biochem. 262 (1): 230–9. PMID 10231386.
Trommsdorff M, Gotthardt M, Hiesberger T, et al. (1999). "Reeler/Disabled-like disruption of neuronal migration in knockout mice lacking the VLDL receptor and ApoE receptor 2.". Cell 97 (6): 689–701. PMID 10380922.
Riddell DR, Vinogradov DV, Stannard AK, et al. (1999). "Identification and characterization of LRP8 (apoER2) in human blood platelets.". J. Lipid Res. 40 (10): 1925–30. PMID 10508213.
D'Arcangelo G, Homayouni R, Keshvara L, et al. (1999). "Reelin is a ligand for lipoprotein receptors.". Neuron 24 (2): 471–9. PMID 10571240.
Korschineck I, Ziegler S, Breuss J, et al. (2001). "Identification of a novel exon in apolipoprotein E receptor 2 leading to alternatively spliced mRNAs found in cells of the vascular wall but not in neuronal tissue.". J. Biol. Chem. 276 (16): 13192–7. doi:10.1074/jbc.M011795200. PMID 11152697.
Riddell DR, Sun XM, Stannard AK, et al. (2001). "Localization of apolipoprotein E receptor 2 to caveolae in the plasma membrane.". J. Lipid Res. 42 (6): 998–1002. PMID 11369809.
Weeber EJ, Beffert U, Jones C, et al. (2002). "Reelin and ApoE receptors cooperate to enhance hippocampal synaptic plasticity and learning.". J. Biol. Chem. 277 (42): 39944–52. doi:10.1074/jbc.M205147200. PMID 12167620.
Stockinger W, Sailler B, Strasser V, et al. (2002). "The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor.". EMBO J. 21 (16): 4259–67. PMID 12169628.
Ma SL, Ng HK, Baum L, et al. (2003). "Low-density lipoprotein receptor-related protein 8 (apolipoprotein E receptor 2) gene polymorphisms in Alzheimer's disease.". Neurosci. Lett. 332 (3): 216–8. PMID 12399018.
Koch S, Strasser V, Hauser C, et al. (2003). "A secreted soluble form of ApoE receptor 2 acts as a dominant-negative receptor and inhibits Reelin signaling.". EMBO J. 21 (22): 5996–6004. PMID 12426372.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Sun XM, Soutar AK (2003). "The transmembrane domain and PXXP motifs of ApoE receptor 2 exclude it from carrying out clathrin-mediated endocytosis.". J. Biol. Chem. 278 (22): 19926–32. doi:10.1074/jbc.M302047200. PMID 12621059.
Benhayon D, Magdaleno S, Curran T (2003). "Binding of purified Reelin to ApoER2 and VLDLR mediates tyrosine phosphorylation of Disabled-1.". Brain Res. Mol. Brain Res. 112 (1-2): 33–45. PMID 12670700.
Sacre SM, Stannard AK, Owen JS (2003). "Apolipoprotein E (apoE) isoforms differentially induce nitric oxide production in endothelial cells.". FEBS Lett. 540 (1-3): 181–7. PMID 12681505.
Lutters BC, Derksen RH, Tekelenburg WL, et al. (2003). "Dimers of beta 2-glycoprotein I increase platelet deposition to collagen via interaction with phospholipids and the apolipoprotein E receptor 2'.". J. Biol. Chem. 278 (36): 33831–8. doi:10.1074/jbc.M212655200. PMID 12807892.
Bajari TM, Strasser V, Nimpf J, Schneider WJ (2003). "A model for modulation of leptin activity by association with clusterin.". FASEB J. 17 (11): 1505–7. doi:10.1096/fj.02-1106fje. PMID 12824284.
May P, Bock HH, Nimpf J, Herz J (2003). "Differential glycosylation regulates processing of lipoprotein receptors by gamma-secretase.". J. Biol. Chem. 278 (39): 37386–92. doi:10.1074/jbc.M305858200. PMID 12871934.