Long-chain-fatty-acyl-CoA reductase

From Wikipedia, the free encyclopedia

In enzymology, a long-chain-fatty-acyl-CoA reductase (EC 1.2.1.50) is an enzyme that catalyzes the chemical reaction

a long-chain aldehyde + CoA + NADP⁺ a long-chain acyl-CoA + NADPH + H⁺

The 3 substrates of this enzyme are long-chain aldehyde, CoA, and NADP⁺, whereas its 3 products are long-chain acyl-CoA, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is long-chain-aldehyde:NADP+ oxidoreductase (acyl-CoA-forming). Other names in common use include acyl-CoA reductase, and acyl coenzyme A reductase.

[edit] References

• IUBMB entry for 1.2.1.50
• BRENDA references for 1.2.1.50 (Recommended.)
• PubMed references for 1.2.1.50
• PubMed Central references for 1.2.1.50
• Google Scholar references for 1.2.1.50
• Riendeau D, Rodriguez A, Meighen E (1982). "Resolution of the fatty acid reductase from Photobacterium phosphoreum into acyl protein synthetase and acyl-CoA reductase activities. Evidence for an enzyme complex". J. Biol. Chem. 257: 6908–15. PMID 7085612. 
• Wall L and Meighen EA (1986). "Subunit structure of the fatty-acid reductase complex from Photobacterium phosphoreum". Biochemistry 25: 4315–4321. doi:10.1021/bi00363a021. 

[edit] External links

The CAS registry number for this enzyme class is 50936-56-6.

• IUBMB entry for 1.2.1.50

• KEGG entry for 1.2.1.50

• BRENDA entry for 1.2.1.50

• NiceZyme view of 1.2.1.50

• EC2PDB: PDB structures for 1.2.1.50

• PRIAM entry for 1.2.1.50

• PUMA2 entry for 1.2.1.50

• IntEnz: Integrated Enzyme entry for 1.2.1.50

• MetaCyc entry for 1.2.1.50

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050062: long-chain-fatty-acyl-CoA reductase

• AMIGO entry for GO code 0050062: long-chain-fatty-acyl-CoA reductase