Long-chain-fatty-acid-luciferin-component ligase

From Wikipedia, the free encyclopedia

In enzymology, a long-chain-fatty-acid-luciferin-component ligase (EC 6.2.1.19) is an enzyme that catalyzes the chemical reaction

ATP + an acid + protein AMP + diphosphate + an acyl-protein thioester

The 3 substrates of this enzyme are ATP, acid, and protein, whereas its 3 products are AMP, diphosphate, and acyl-protein thioester.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is long-chain-fatty-acid:protein ligase (AMP-forming). This enzyme is also called acyl-protein synthetase.

[edit] References

• IUBMB entry for 6.2.1.19
• BRENDA references for 6.2.1.19 (Recommended.)
• PubMed references for 6.2.1.19
• PubMed Central references for 6.2.1.19
• Google Scholar references for 6.2.1.19
• Riendeau D, Rodriguez A, Meighen E (1982). "Resolution of the fatty acid reductase from Photobacterium phosphoreum into acyl protein synthetase and acyl-CoA reductase activities. Evidence for an enzyme complex". J. Biol. Chem. 257: 6908–15. PMID 7085612. 
• Wall L and Meighen EA (1986). "Subunit structure of the fatty-acid reductase complex from Photobacterium phosphoreum". Biochemistry 25: 4315–4321. doi:10.1021/bi00363a021. 

[edit] External links

The CAS registry number for this enzyme class is 82657-98-5.

• IUBMB entry for 6.2.1.19

• KEGG entry for 6.2.1.19

• BRENDA entry for 6.2.1.19

• NiceZyme view of 6.2.1.19

• EC2PDB: PDB structures for 6.2.1.19

• PRIAM entry for 6.2.1.19

• PUMA2 entry for 6.2.1.19

• IntEnz: Integrated Enzyme entry for 6.2.1.19

• MetaCyc entry for 6.2.1.19

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047474: long-chain-fatty-acid-luciferin-component ligase

• AMIGO entry for GO code 0047474: long-chain-fatty-acid-luciferin-component ligase