Long-chain-fatty-acid-(acyl-carrier-protein) ligase
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In enzymology, a long-chain-fatty-acid-[acyl-carrier-protein] ligase (EC 6.2.1.20) is an enzyme that catalyzes the chemical reaction
- ATP + an acid + [acyl-carrier-protein]
AMP + diphosphate + acyl-[acyl-carrier-protein]
The 3 substrates of this enzyme are ATP, acid, and [[[acyl-carrier-protein]]], whereas its 3 products are AMP, diphosphate, and [[acyl-[acyl-carrier-protein]]].
This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is long-chain-fatty-acid:[acyl-carrier-protein] ligase (AMP-forming). Other names in common use include acyl-[acyl-carrier-protein] synthetase, acyl-[acyl carrier protein] synthetase, acyl-ACP synthetase, acyl-[acyl-carrier-protein]synthetase, stearoyl-ACP synthetase, and acyl-acyl carrier protein synthetase. This enzyme participates in fatty acid metabolism.
[edit] References
- IUBMB entry for 6.2.1.20
- BRENDA references for 6.2.1.20 (Recommended.)
- PubMed references for 6.2.1.20
- PubMed Central references for 6.2.1.20
- Google Scholar references for 6.2.1.20
- Ray TK, Cronan JE Jr (1976). "Activation of long chain fatty acids with acyl carrier protein: demonstration of a new enzyme, acyl-acyl carrier protein synthetase, in Escherichia coli". Proc. Natl. Acad. Sci. U. S. A. 73: 4374–8. doi:. PMID 794875.
[edit] External links
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- The CAS registry number for this enzyme class is 77322-37-3.
[edit] Gene Ontology (GO) codes
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