Long-chain-enoyl-CoA hydratase

From Wikipedia, the free encyclopedia

In enzymology, a long-chain-enoyl-CoA hydratase (EC 4.2.1.74) is an enzyme that catalyzes the chemical reaction

(3S)-3-hydroxyacyl-CoA trans-2-enoyl-CoA + H₂O

Hence, this enzyme has one substrate, (3S)-3-hydroxyacyl-CoA, and two products, trans-2-enoyl-CoA and H₂O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is long-chain-(3S)-3-hydroxyacyl-CoA hydro-lyase. This enzyme is also called long-chain enoyl coenzyme A hydratase. This enzyme participates in fatty acid elongation in mitochondria and fatty acid metabolism.

[edit] References

• IUBMB entry for 4.2.1.74
• BRENDA references for 4.2.1.74 (Recommended.)
• PubMed references for 4.2.1.74
• PubMed Central references for 4.2.1.74
• Google Scholar references for 4.2.1.74
• Fong JC, Schulz H (1977). "Purification and properties of pig heart crotonase and the presence of short chain and long chain enoyl coenzyme A hydratases in pig and guinea pig tissues". J. Biol. Chem. 252: 542–7. PMID 833142. 
• Schulz H (1974). "Long chain enoyl coenzyme A hydratase from pig heart". J. Biol. Chem. 249: 2704–9. PMID 4828315. 

[edit] External links

The CAS registry number for this enzyme class is 62009-81-8.

• IUBMB entry for 4.2.1.74

• KEGG entry for 4.2.1.74

• BRENDA entry for 4.2.1.74

• NiceZyme view of 4.2.1.74

• EC2PDB: PDB structures for 4.2.1.74

• PRIAM entry for 4.2.1.74

• PUMA2 entry for 4.2.1.74

• IntEnz: Integrated Enzyme entry for 4.2.1.74

• MetaCyc entry for 4.2.1.74

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0016508: long-chain-enoyl-CoA hydratase

• AMIGO entry for GO code 0016508: long-chain-enoyl-CoA hydratase