Long-chain-acyl-CoA dehydrogenase

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In enzymology, a long-chain-acyl-CoA dehydrogenase (EC 1.3.99.13) is an enzyme that catalyzes the chemical reaction

acyl-CoA + acceptor $\rightleftharpoons$ 2,3-dehydroacyl-CoA + reduced acceptor

Thus, the two substrates of this enzyme are acyl-CoA and acceptor, whereas its two products are 2,3-dehydroacyl-CoA and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with other acceptors. The systematic name of this enzyme class is long-chain-acyl-CoA:acceptor 2,3-oxidoreductase. Other names in common use include palmitoyl-CoA dehydrogenase, palmitoyl-coenzyme A dehydrogenase, long-chain acyl-coenzyme A dehydrogenase, and long-chain-acyl-CoA:(acceptor) 2,3-oxidoreductase. This enzyme participates in fatty acid metabolism and ppar signaling pathway. It employs one cofactor, FAD.

[edit] References

IUBMB entry for 1.3.99.13
BRENDA references for 1.3.99.13 (Recommended.)
PubMed references for 1.3.99.13
PubMed Central references for 1.3.99.13
Google Scholar references for 1.3.99.13
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HAUGE JG, CRANE FL, BEINERT H (1956). "On the mechanism of dehydrogenation of fatty acyl derivatives of coenzyme A. III. Palmityl coA dehydrogenase". J. Biol. Chem. 219: 727–33. PMID 13319294.
Ikeda Y, Okamura-Ikeda K, Tanaka K (1985). "Purification and characterization of short-chain, medium-chain, and long-chain acyl-CoA dehydrogenases from rat liver mitochondria Isolation of the holo- and apoenzymes and conversion of the apoenzyme to the holoenzyme". J. Biol. Chem. 260: 1311–25. PMID 3968063.