LOC4951

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Oncomodulin
PDB rendering based on 1omd.
Available structures: 1omd, 1rro, 1ttx
Identifiers
Symbol(s) OCM; OM; ONCM; LOC654231
External IDs OMIM: 164795 MGI: 97401 HomoloGene: 4511
Orthologs
Human Mouse
Entrez 4951 18261
Ensembl n/a ENSMUSG00000029618
Uniprot n/a P51879
Refseq NM_006188 (mRNA)
NP_006179 (protein)		 XM_001001609 (mRNA)
XP_001001609 (protein)
Location n/a Chr 5: 144.27 - 144.28 Mb
Pubmed search [1] [2]

Oncomodulin, also known as OCM, is a human gene.[1]

Oncomodulin is a high-affinity calcium ion-binding protein. It belongs to the superfamily of calmodulin proteins, also known as the EF-hand proteins. Oncomodulin is an oncodevelopmental protein found in early embryonic cells in the placenta and also in tumors.[1]

[edit] References

  1. ^ a b Entrez Gene: OCM oncomodulin.

[edit] Further reading

  • Pauls TL, Cox JA, Berchtold MW (1996). "The Ca2+(-)binding proteins parvalbumin and oncomodulin and their genes: new structural and functional findings.". Biochim. Biophys. Acta 1306 (1): 39-54. PMID 8611623. 
  • Belkacemi L, Simoneau L, Lafond J (2003). "Calcium-binding proteins: distribution and implication in mammalian placenta.". Endocrine 19 (1): 57-64. PMID 12583602. 
  • Ritzler JM, Sawhney R, Geurts van Kessel AH, et al. (1992). "The genes for the highly homologous Ca(2+)-binding proteins oncomodulin and parvalbumin are not linked in the human genome.". Genomics 12 (3): 567-72. PMID 1559707. 
  • Palmer EJ, MacManus JP, Mutus B (1990). "Inhibition of glutathione reductase by oncomodulin.". Arch. Biochem. Biophys. 277 (1): 149-54. PMID 2306116. 
  • Mutus B, Palmer EJ, MacManus JP (1988). "Disulfide-linked dimer of oncomodulin: comparison to calmodulin.". Biochemistry 27 (15): 5615-22. PMID 3179268. 
  • Gillen MF, Banville D, Rutledge RG, et al. (1987). "A complete complementary DNA for the oncodevelopmental calcium-binding protein, oncomodulin.". J. Biol. Chem. 262 (11): 5308-12. PMID 3558395. 
  • MacManus JP, Brewer LM, Whitfield JF (1985). "The widely-distributed tumour protein, oncomodulin, is a normal constituent of human and rodent placentas.". Cancer Lett. 27 (2): 145-51. PMID 4005827. 
  • Blum JK, Berchtold MW (1994). "Calmodulin-like effect of oncomodulin on cell proliferation.". J. Cell. Physiol. 160 (3): 455-62. doi:10.1002/jcp.1041600308. PMID 8077283. 
  • Föhr UG, Weber BR, Müntener M, et al. (1993). "Human alpha and beta parvalbumins. Structure and tissue-specific expression.". Eur. J. Biochem. 215 (3): 719-27. PMID 8354278. 
  • Sakaguchi N, Henzl MT, Thalmann I, et al. (2000). "Oncomodulin is expressed exclusively by outer hair cells in the organ of Corti.". J. Histochem. Cytochem. 46 (1): 29-40. PMID 9405492. 
  • "Toward a complete human genome sequence." (1999). Genome Res. 8 (11): 1097-108. PMID 9847074. 
  • Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression.". Nat. Biotechnol. 19 (5): 440-5. doi:10.1038/88107. PMID 11329013. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157-64. doi:10.1038/nature01782. PMID 12853948. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Babini E, Bertini I, Capozzi F, et al. (2005). "Solution structure of human beta-parvalbumin and structural comparison with its paralog alpha-parvalbumin and with their rat orthologs.". Biochemistry 43 (51): 16076-85. doi:10.1021/bi048388o. PMID 15610002. 
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