LNX1

From Wikipedia, the free encyclopedia

Ligand of numb-protein X 1

Identifiers

LNX1; MPDZ; LNX; PDZRN2

External IDs

OMIM: 609732 MGI: 1278335 HomoloGene: 7819

Gene ontology
Molecular Function:	• ubiquitin-protein ligase activity • protein binding • zinc ion binding • ligase activity • PDZ domain binding • metal ion binding
Cellular Component:	• cytoplasm
Biological Process:	• ubiquitin cycle • protein ubiquitination during ubiquitin-dependent protein catabolic process • protein homooligomerization

Orthologs

Human

Mouse

Refseq

NM_032622 (mRNA)
NP_116011 (protein)

NM_010727 (mRNA)
NP_034857 (protein)

Location

Chr 4: 54.02 - 54.15 Mb

Chr 5: 74.87 - 74.98 Mb

Pubmed search

[1]

[2]

Ligand of numb-protein X 1, also known as LNX1, is a human gene.^[1]

[edit] References

^ Entrez Gene: LNX1 ligand of numb-protein X 1.

[edit] Further reading

Dho SE, Jacob S, Wolting CD, et al. (1998). "The mammalian numb phosphotyrosine-binding domain. Characterization of binding specificity and identification of a novel PDZ domain-containing numb binding protein, LNX.". J. Biol. Chem. 273 (15): 9179–87. PMID 9535908.
Xie Y, Zhao W, Wang W, et al. (2002). "Identification of a human LNX protein containing multiple PDZ domains.". Biochem. Genet. 39 (3-4): 117–26. PMID 11521506.
Nie J, McGill MA, Dermer M, et al. (2002). "LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradation.". EMBO J. 21 (1-2): 93–102. doi:10.1093/emboj/21.1.93. PMID 11782429.
Rice DS, Northcutt GM, Kurschner C (2002). "The Lnx family proteins function as molecular scaffolds for Numb family proteins.". Mol. Cell. Neurosci. 18 (5): 525–40. doi:10.1006/mcne.2001.1024. PMID 11922143.
Sollerbrant K, Raschperger E, Mirza M, et al. (2003). "The Coxsackievirus and adenovirus receptor (CAR) forms a complex with the PDZ domain-containing protein ligand-of-numb protein-X (LNX).". J. Biol. Chem. 278 (9): 7439–44. doi:10.1074/jbc.M205927200. PMID 12468544.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Katoh M, Katoh M (2004). "Identification and characterization of PDZRN3 and PDZRN4 genes in silico.". Int. J. Mol. Med. 13 (4): 607–13. PMID 15010864.
Armbruester V, Sauter M, Roemer K, et al. (2004). "Np9 protein of human endogenous retrovirus K interacts with ligand of numb protein X.". J. Virol. 78 (19): 10310–9. doi:10.1128/JVI.78.19.10310-10319.2004. PMID 15367597.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Chen J, Xu J, Zhao W, et al. (2005). "Characterization of human LNX, a novel ligand of Numb protein X that is downregulated in human gliomas.". Int. J. Biochem. Cell Biol. 37 (11): 2273–83. doi:10.1016/j.biocel.2005.02.028. PMID 16002321.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Weiss A, Baumgartner M, Radziwill G, et al. (2007). "c-Src is a PDZ interaction partner and substrate of the E3 ubiquitin ligase Ligand-of-Numb protein X1.". FEBS Lett. 581 (26): 5131–6. doi:10.1016/j.febslet.2007.09.062. PMID 17936276.