LMX1A

From Wikipedia, the free encyclopedia

LIM homeobox transcription factor 1, alpha

Identifiers

LMX1A; LMX-1; LMX1; LMX1.1; MGC87616

External IDs

OMIM: 600298 MGI: 1888519 HomoloGene: 24921

Gene ontology
Molecular Function:	• DNA binding • transcription factor activity • zinc ion binding • sequence-specific DNA binding • metal ion binding
Cellular Component:	• nucleus
Biological Process:	• regulation of transcription, DNA-dependent • multicellular organismal development • axon guidance • central nervous system development • neuron differentiation • negative regulation of neuron differentiation

Orthologs

Human

Mouse

Refseq

NM_001033507 (mRNA)
NP_001028679 (protein)

NM_033652 (mRNA)
NP_387501 (protein)

Location

Chr 1: 163.44 - 163.59 Mb

Chr 1: 169.53 - 169.69 Mb

Pubmed search

[1]

[2]

LIM homeobox transcription factor 1, alpha, also known as LMX1A, is a human gene.^[1]

[edit] References

^ Entrez Gene: LMX1A LIM homeobox transcription factor 1, alpha.

[edit] Further reading

German MS, Wang J, Chadwick RB, Rutter WJ (1992). "Synergistic activation of the insulin gene by a LIM-homeo domain protein and a basic helix-loop-helix protein: building a functional insulin minienhancer complex.". Genes Dev. 6 (11): 2165–76. PMID 1358758.
German MS, Wang J, Fernald AA, et al. (1995). "Localization of the genes encoding two transcription factors, LMX1 and CDX3, regulating insulin gene expression to human chromosomes 1 and 13.". Genomics 24 (2): 403–4. doi:10.1006/geno.1994.1639. PMID 7698771.
Jurata LW, Gill GN (1997). "Functional analysis of the nuclear LIM domain interactor NLI.". Mol. Cell. Biol. 17 (10): 5688–98. PMID 9315627.
Iannotti CA, Inoue H, Bernal E, et al. (1998). "Identification of a human LMX1 (LMX1.1)-related gene, LMX1.2: tissue-specific expression and linkage mapping on chromosome 9.". Genomics 46 (3): 520–4. doi:10.1006/geno.1997.5075. PMID 9441763.
Jurata LW, Pfaff SL, Gill GN (1998). "The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors.". J. Biol. Chem. 273 (6): 3152–7. PMID 9452425.
Thameem F, Wolford JK, Wang J, et al. (2002). "Cloning, expression and genomic structure of human LMX1A, and variant screening in Pima Indians.". Gene 290 (1-2): 217–25. PMID 12062816.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Millen KJ, Millonig JH, Hatten ME (2004). "Roof plate and dorsal spinal cord dl1 interneuron development in the dreher mutant mouse.". Dev. Biol. 270 (2): 382–92. doi:10.1016/j.ydbio.2004.03.008. PMID 15183721.
Hassel S, Eichner A, Yakymovych M, et al. (2004). "Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry.". Proteomics 4 (5): 1346–58. doi:10.1002/pmic.200300770. PMID 15188402.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.