LMTK2

From Wikipedia, the free encyclopedia

Lemur tyrosine kinase 2

Identifiers

LMTK2; AATYK2; BREK; KIAA1079; KPI-2; KPI2; LMR2; cprk

External IDs

Gene ontology
Molecular Function:	• nucleotide binding • protein serine/threonine kinase activity • protein-tyrosine kinase activity • protein phosphatase inhibitor activity • protein binding • ATP binding • transferase activity
Cellular Component:	• membrane • integral to membrane
Biological Process:	• protein amino acid autophosphorylation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014916 (mRNA)
NP_055731 (protein)

XM_001001626 (mRNA)
XP_001001626 (protein)

Location

Chr 7: 97.57 - 97.67 Mb

Chr 5: 144.35 - 144.44 Mb

Pubmed search

[1]

[2]

Lemur tyrosine kinase 2, also known as LMTK2, is a human gene.^[1]

[edit] References

^ Entrez Gene: LMTK2 lemur tyrosine kinase 2.

[edit] Further reading

Eeles RA, Kote-Jarai Z, Giles GG, et al. (2008). "Multiple newly identified loci associated with prostate cancer susceptibility.". Nat. Genet. 40 (3): 316–21. doi:10.1038/ng.90. PMID 18264097.
Chibalina MV, Seaman MN, Miller CC, et al. (2008). "Myosin VI and its interacting protein LMTK2 regulate tubule formation and transport to the endocytic recycling compartment.". J. Cell. Sci. 120 (Pt 24): 4278–88. doi:10.1242/jcs.014217. PMID 18029400.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Wang H, Brautigan DL (2007). "Peptide microarray analysis of substrate specificity of the transmembrane Ser/Thr kinase KPI-2 reveals reactivity with cystic fibrosis transmembrane conductance regulator and phosphorylase.". Mol. Cell Proteomics 5 (11): 2124–30. doi:10.1074/mcp.M600188-MCP200. PMID 16887929.
Kawa S, Fujimoto J, Tezuka T, et al. (2004). "Involvement of BREK, a serine/threonine kinase enriched in brain, in NGF signalling.". Genes Cells 9 (3): 219–32. PMID 15005709.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
Kesavapany S, Lau KF, Ackerley S, et al. (2003). "Identification of a novel, membrane-associated neuronal kinase, cyclin-dependent kinase 5/p35-regulated kinase.". J. Neurosci. 23 (12): 4975–83. PMID 12832520.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMID 12690205.
Wang H, Brautigan DL (2003). "A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2.". J. Biol. Chem. 277 (51): 49605–12. doi:10.1074/jbc.M209335200. PMID 12393858.
Kikuno R, Nagase T, Ishikawa K, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (3): 197–205. PMID 10470851.