LMO2

From Wikipedia, the free encyclopedia


LIM domain only 2 (rhombotin-like 1)
Identifiers
Symbol(s) LMO2; RBTN2; RBTNL1; RHOM2; TTG2
External IDs OMIM: 180385 MGI: 102811 HomoloGene: 4072
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 4005 16909
Ensembl ENSG00000135363 ENSMUSG00000032698
Uniprot P25791 Q544Z2
Refseq NM_005574 (mRNA)
NP_005565 (protein)		 XM_001001351 (mRNA)
XP_001001351 (protein)
Location Chr 11: 33.84 - 33.87 Mb Chr 2: 103.77 - 103.78 Mb
Pubmed search [1] [2]

LIM domain only 2 (rhombotin-like 1), also known as LMO2, is a human gene.

LMO2 encodes a cysteine-rich, two LIM-domain protein that is required for yolk sac erythropoiesis. The LMO2 protein has a central and crucial role in hematopoietic development and is highly conserved. The LMO2 transcription start site is located approximately 25 kb downstream from the 11p13 T-cell translocation cluster (11p13 ttc), where a number T-cell acute lymphoblastic leukemia-specific translocations occur.[1]

[edit] References

  1. ^ Entrez Gene: LMO2 LIM domain only 2 (rhombotin-like 1).

[edit] Further reading

  • Royer-Pokora B, Loos U, Ludwig WD (1991). "TTG-2, a new gene encoding a cysteine-rich protein with the LIM motif, is overexpressed in acute T-cell leukaemia with the t(11;14)(p13;q11).". Oncogene 6 (10): 1887–93. PMID 1923511. 
  • Boehm T, Foroni L, Kaneko Y, et al. (1991). "The rhombotin family of cysteine-rich LIM-domain oncogenes: distinct members are involved in T-cell translocations to human chromosomes 11p15 and 11p13.". Proc. Natl. Acad. Sci. U.S.A. 88 (10): 4367–71. PMID 2034676. 
  • Boehm T, Spillantini MG, Sofroniew MV, et al. (1991). "Developmentally regulated and tissue specific expression of mRNAs encoding the two alternative forms of the LIM domain oncogene rhombotin: evidence for thymus expression.". Oncogene 6 (5): 695–703. PMID 2052354. 
  • Dong WF, Xu Y, Hu QL, et al. (1995). "Molecular characterization of a chromosome translocation breakpoint t(11;14)(p13;q11) from the cell line KOPT-K1.". Leukemia 9 (11): 1812–7. PMID 7475267. 
  • Osada H, Grutz G, Axelson H, et al. (1995). "Association of erythroid transcription factors: complexes involving the LIM protein RBTN2 and the zinc-finger protein GATA1.". Proc. Natl. Acad. Sci. U.S.A. 92 (21): 9585–9. PMID 7568177. 
  • Sánchez-García I, Axelson H, Rabbitts TH (1995). "Functional diversity of LIM proteins: amino-terminal activation domains in the oncogenic proteins RBTN1 and RBTN2.". Oncogene 10 (7): 1301–6. PMID 7731680. 
  • Wadman I, Li J, Bash RO, et al. (1994). "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia.". EMBO J. 13 (20): 4831–9. PMID 7957052. 
  • Valge-Archer VE, Osada H, Warren AJ, et al. (1994). "The LIM protein RBTN2 and the basic helix-loop-helix protein TAL1 are present in a complex in erythroid cells.". Proc. Natl. Acad. Sci. U.S.A. 91 (18): 8617–21. PMID 8078932. 
  • Wilkinson DA, Neale GA, Mao S, et al. (1997). "Elf-2, a rhombotin-2 binding ets transcription factor: discovery and potential role in T cell leukemia.". Leukemia 11 (1): 86–96. PMID 9001422. 
  • Mao S, Neale GA, Goorha RM (1997). "T-cell oncogene rhombotin-2 interacts with retinoblastoma-binding protein 2.". Oncogene 14 (13): 1531–9. doi:10.1038/sj.onc.1200988. PMID 9129143. 
  • Osada H, Grutz GG, Axelson H, et al. (1997). "LIM-only protein Lmo2 forms a protein complex with erythroid transcription factor GATA-1.". Leukemia 11 Suppl 3: 307–12. PMID 9209374. 
  • Wadman IA, Osada H, Grütz GG, et al. (1997). "The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins.". EMBO J. 16 (11): 3145–57. doi:10.1093/emboj/16.11.3145. PMID 9214632. 
  • Visvader JE, Mao X, Fujiwara Y, et al. (1998). "The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation.". Proc. Natl. Acad. Sci. U.S.A. 94 (25): 13707–12. PMID 9391090. 
  • Jurata LW, Pfaff SL, Gill GN (1998). "The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors.". J. Biol. Chem. 273 (6): 3152–7. PMID 9452425. 
  • Kenny DA, Jurata LW, Saga Y, Gill GN (1998). "Identification and characterization of LMO4, an LMO gene with a novel pattern of expression during embryogenesis.". Proc. Natl. Acad. Sci. U.S.A. 95 (19): 11257–62. PMID 9736723. 
  • Ono Y, Fukuhara N, Yoshie O (1998). "TAL1 and LIM-only proteins synergistically induce retinaldehyde dehydrogenase 2 expression in T-cell acute lymphoblastic leukemia by acting as cofactors for GATA3.". Mol. Cell. Biol. 18 (12): 6939–50. PMID 9819382. 
  • Bach I, Rodriguez-Esteban C, Carrière C, et al. (1999). "RLIM inhibits functional activity of LIM homeodomain transcription factors via recruitment of the histone deacetylase complex.". Nat. Genet. 22 (4): 394–9. doi:10.1038/11970. PMID 10431247. 
  • Vitelli L, Condorelli G, Lulli V, et al. (2000). "A pentamer transcriptional complex including tal-1 and retinoblastoma protein downmodulates c-kit expression in normal erythroblasts.". Mol. Cell. Biol. 20 (14): 5330–42. PMID 10866689. 
  • Davenport J, Neale GA, Goorha R (2000). "Identification of genes potentially involved in LMO2-induced leukemogenesis.". Leukemia 14 (11): 1986–96. PMID 11069036. 
  • Sum EY, Peng B, Yu X, et al. (2002). "The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity.". J. Biol. Chem. 277 (10): 7849–56. doi:10.1074/jbc.M110603200. PMID 11751867. 
 This article on a gene on chromosome 11 is a stub. You can help Wikipedia by expanding it.