Liver receptor homolog-1

From Wikipedia, the free encyclopedia


Nuclear receptor subfamily 5, group A, member 2
PDB rendering based on 1yok.
Available structures: 1yok, 1yuc, 1zdu, 2a66, 2ff0
Identifiers
Symbol(s) NR5A2; B1F; B1F2; CPF; FTF; FTZ-F1; FTZ-F1beta; LRH-1; hB1F; hB1F-2
External IDs OMIM: 604453 MGI1346834 HomoloGene20827
Orthologs
Human Mouse
Entrez 2494 26424
Ensembl ENSG00000116833 ENSMUSG00000026398
Uniprot O00482 Q1WLP7
Refseq NM_003822 (mRNA)
NP_003813 (protein)
XM_990082 (mRNA)
XP_995176 (protein)
Location Chr 1: 198.26 - 198.41 Mb Chr 1: 138.66 - 138.78 Mb
Pubmed search [1] [2]

The liver receptor homolog-1 (LRH-1) protein is a member of the nuclear receptor family of intracellular transcription factors and is encoded by the NR5A2 gene (nuclear receptor subfamily 5, group A, member 2).[1][2]

LRH-1 plays a critical role in the regulation of development, cholesterol transport, bile acid homeostasis and steroidogenesis.[3]

[edit] References

  1. ^ Bernier D, Thomassin H, Allard D, et al (1993). "Functional analysis of developmentally regulated chromatin-hypersensitive domains carrying the alpha 1-fetoprotein gene promoter and the albumin/alpha 1-fetoprotein intergenic enhancer.". Mol. Cell. Biol. 13 (3): 1619–33. PMID 7680097. 
  2. ^ Galarneau L, Drouin R, Bélanger L (1998). "Assignment of the fetoprotein transcription factor gene (FTF) to human chromosome band 1q32.11 by in situ hybridization.". Cytogenet. Cell Genet. 82 (3-4): 269–70. PMID 9858833. 
  3. ^ Fayard E, Auwerx J, Schoonjans K (2004). "LRH-1: an orphan nuclear receptor involved in development, metabolism and steroidogenesis.". Trends Cell Biol. 14 (5): 250–60. doi:10.1016/j.tcb.2004.03.008. PMID 15130581. 

[edit] Further reading

  • Bernier D, Thomassin H, Allard D, et al. (1993). "Functional analysis of developmentally regulated chromatin-hypersensitive domains carrying the alpha 1-fetoprotein gene promoter and the albumin/alpha 1-fetoprotein intergenic enhancer.". Mol. Cell. Biol. 13 (3): 1619–33. PMID 7680097. 
  • Wong M, Ramayya MS, Chrousos GP, et al. (1997). "Cloning and sequence analysis of the human gene encoding steroidogenic factor 1.". J. Mol. Endocrinol. 17 (2): 139–47. PMID 8938589. 
  • Li M, Xie YH, Kong YY, et al. (1998). "Cloning and characterization of a novel human hepatocyte transcription factor, hB1F, which binds and activates enhancer II of hepatitis B virus.". J. Biol. Chem. 273 (44): 29022–31. PMID 9786908. 
  • Galarneau L, Drouin R, Bélanger L (1999). "Assignment of the fetoprotein transcription factor gene (FTF) to human chromosome band 1q32.11 by in situ hybridization.". Cytogenet. Cell Genet. 82 (3-4): 269–70. PMID 9858833. 
  • Nitta M, Ku S, Brown C, et al. (1999). "CPF: an orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7alpha-hydroxylase gene.". Proc. Natl. Acad. Sci. U.S.A. 96 (12): 6660–5. PMID 10359768. 
  • Goodwin B, Jones SA, Price RR, et al. (2000). "A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis.". Mol. Cell 6 (3): 517–26. PMID 11030332. 
  • Wang ZN, Bassett M, Rainey WE (2001). "Liver receptor homologue-1 is expressed in the adrenal and can regulate transcription of 11 beta-hydroxylase.". J. Mol. Endocrinol. 27 (2): 255–8. PMID 11564608. 
  • Zhang CK, Lin W, Cai YN, et al. (2001). "Characterization of the genomic structure and tissue-specific promoter of the human nuclear receptor NR5A2 (hB1F) gene.". Gene 273 (2): 239–49. PMID 11595170. 
  • Lee YK, Moore DD (2002). "Dual mechanisms for repression of the monomeric orphan receptor liver receptor homologous protein-1 by the orphan small heterodimer partner.". J. Biol. Chem. 277 (4): 2463–7. doi:10.1074/jbc.M105161200. PMID 11668176. 
  • Clyne CD, Speed CJ, Zhou J, Simpson ER (2002). "Liver receptor homologue-1 (LRH-1) regulates expression of aromatase in preadipocytes.". J. Biol. Chem. 277 (23): 20591–7. doi:10.1074/jbc.M201117200. PMID 11927588. 
  • Brendel C, Gelman L, Auwerx J (2003). "Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism.". Mol. Endocrinol. 16 (6): 1367–77. PMID 12040021. 
  • Sirianni R, Seely JB, Attia G, et al. (2002). "Liver receptor homologue-1 is expressed in human steroidogenic tissues and activates transcription of genes encoding steroidogenic enzymes.". J. Endocrinol. 174 (3): R13–7. PMID 12208674. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Sablin EP, Krylova IN, Fletterick RJ, Ingraham HA (2003). "Structural basis for ligand-independent activation of the orphan nuclear receptor LRH-1.". Mol. Cell 11 (6): 1575–85. PMID 12820970. 
  • Privalsky ML (2003). "Activation incarnate.". Dev. Cell 5 (1): 1–2. PMID 12852843. 
  • Fayard E, Schoonjans K, Annicotte JS, Auwerx J (2003). "Liver receptor homolog 1 controls the expression of carboxyl ester lipase.". J. Biol. Chem. 278 (37): 35725–31. doi:10.1074/jbc.M302370200. PMID 12853459. 
  • Annicotte JS, Fayard E, Swift GH, et al. (2003). "Pancreatic-duodenal homeobox 1 regulates expression of liver receptor homolog 1 during pancreas development.". Mol. Cell. Biol. 23 (19): 6713–24. PMID 12972592. 
  • Peng N, Kim JW, Rainey WE, et al. (2004). "The role of the orphan nuclear receptor, liver receptor homologue-1, in the regulation of human corpus luteum 3beta-hydroxysteroid dehydrogenase type II.". J. Clin. Endocrinol. Metab. 88 (12): 6020–8. PMID 14671206. 
  • Cai YN, Zhou Q, Kong YY, et al. (2004). "LRH-1/hB1F and HNF1 synergistically up-regulate hepatitis B virus gene transcription and DNA replication.". Cell Res. 13 (6): 451–8. doi:10.1038/sj.cr.7290187. PMID 14728801. 
  • Saxena D, Safi R, Little-Ihrig L, Zeleznik AJ (2004). "Liver receptor homolog-1 stimulates the progesterone biosynthetic pathway during follicle-stimulating hormone-induced granulosa cell differentiation.". Endocrinology 145 (8): 3821–9. doi:10.1210/en.2004-0423. PMID 15117876. 

[edit] External links