Liver X receptor beta

From Wikipedia, the free encyclopedia


Nuclear receptor subfamily 1, group H, member 2
PDB rendering based on 1p8d.
Available structures: 1p8d, 1pq6, 1pq9, 1pqc, 1upv, 1upw
Identifiers
Symbol(s) NR1H2; UNR; LXR-b; LXRB; NER; NER-I; RIP15
External IDs OMIM: 600380 MGI1352463 HomoloGene21397
RNA expression pattern

More reference expression data

Orthologs
Human Mouse
Entrez 7376 22260
Ensembl ENSG00000131408 ENSMUSG00000060601
Uniprot P55055 Q8BP65
Refseq NM_007121 (mRNA)
NP_009052 (protein)
XM_001002072 (mRNA)
XP_001002072 (protein)
Location Chr 19: 55.57 - 55.58 Mb Chr 7: 44.42 - 44.42 Mb
Pubmed search [1] [2]

Liver X receptor beta (LXR-β) is a member of the nuclear receptor family of transcription factors. LXR-β is encoded by the NR1H2 gene (nuclear receptor subfamily 1, group H, member 2).[1]

The LX receptors (LXRs) were originally identified as orphan members of the nuclear receptor superfamily because their ligands were unknown. Like other receptors in the family, LXRs heterodimerize with retinoid X receptor (see MIM 180245) and bind to specific response elements (LXREs) characterized by direct repeats separated by 4 nucleotides. Two genes, alpha (LXRA, MIM 602423) and beta, are known to encode LXR proteins (Song et al., 1995).[supplied by OMIM][1]

[edit] References

[edit] Further reading

  • Song C, Hiipakka RA, Kokontis JM, Liao S (1995). "Ubiquitous receptor: structures, immunocytochemical localization, and modulation of gene activation by receptors for retinoic acids and thyroid hormones.". Ann. N. Y. Acad. Sci. 761: 38–49. PMID 7625741. 
  • Seol W, Choi HS, Moore DD (1995). "Isolation of proteins that interact specifically with the retinoid X receptor: two novel orphan receptors.". Mol. Endocrinol. 9 (1): 72–85. PMID 7760852. 
  • Le Beau MM, Song C, Davis EM, et al. (1995). "Assignment of the human ubiquitous receptor gene (UNR) to 19q13.3 using fluorescence in situ hybridization.". Genomics 26 (1): 166–8. PMID 7782080. 
  • Shinar DM, Endo N, Rutledge SJ, et al. (1994). "NER, a new member of the gene family encoding the human steroid hormone nuclear receptor.". Gene 147 (2): 273–6. PMID 7926814. 
  • Song C, Kokontis JM, Hiipakka RA, Liao S (1994). "Ubiquitous receptor: a receptor that modulates gene activation by retinoic acid and thyroid hormone receptors.". Proc. Natl. Acad. Sci. U.S.A. 91 (23): 10809–13. PMID 7971966. 
  • Janowski BA, Grogan MJ, Jones SA, et al. (1999). "Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta.". Proc. Natl. Acad. Sci. U.S.A. 96 (1): 266–71. PMID 9874807. 
  • Feltkamp D, Wiebel FF, Alberti S, Gustafsson JA (1999). "Identification of a novel DNA binding site for nuclear orphan receptor OR1.". J. Biol. Chem. 274 (15): 10421–9. PMID 10187832. 
  • Lee SK, Jung SY, Kim YS, et al. (2001). "Two distinct nuclear receptor-interaction domains and CREB-binding protein-dependent transactivation function of activating signal cointegrator-2.". Mol. Endocrinol. 15 (2): 241–54. PMID 11158331. 
  • Whitney KD, Watson MA, Goodwin B, et al. (2001). "Liver X receptor (LXR) regulation of the LXRalpha gene in human macrophages.". J. Biol. Chem. 276 (47): 43509–15. doi:10.1074/jbc.M106155200. PMID 11546778. 
  • Whitney KD, Watson MA, Collins JL, et al. (2003). "Regulation of cholesterol homeostasis by the liver X receptors in the central nervous system.". Mol. Endocrinol. 16 (6): 1378–85. PMID 12040022. 
  • Brendel C, Schoonjans K, Botrugno OA, et al. (2003). "The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity.". Mol. Endocrinol. 16 (9): 2065–76. PMID 12198243. 
  • Mo J, Fang SJ, Chen W, Blobe GC (2003). "Regulation of ALK-1 signaling by the nuclear receptor LXRbeta.". J. Biol. Chem. 277 (52): 50788–94. doi:10.1074/jbc.M210376200. PMID 12393874. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Williams S, Bledsoe RK, Collins JL, et al. (2003). "X-ray crystal structure of the liver X receptor beta ligand binding domain: regulation by a histidine-tryptophan switch.". J. Biol. Chem. 278 (29): 27138–43. doi:10.1074/jbc.M302260200. PMID 12736258. 
  • Färnegårdh M, Bonn T, Sun S, et al. (2003). "The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands.". J. Biol. Chem. 278 (40): 38821–8. doi:10.1074/jbc.M304842200. PMID 12819202. 
  • Fukuchi J, Song C, Ko AL, Liao S (2004). "Transcriptional regulation of farnesyl pyrophosphate synthase by liver X receptors.". Steroids 68 (7-8): 685–91. PMID 12957674. 
  • Hoerer S, Schmid A, Heckel A, et al. (2004). "Crystal structure of the human liver X receptor beta ligand-binding domain in complex with a synthetic agonist.". J. Mol. Biol. 334 (5): 853–61. PMID 14643652. 
  • Walczak R, Joseph SB, Laffitte BA, et al. (2004). "Transcription of the vascular endothelial growth factor gene in macrophages is regulated by liver X receptors.". J. Biol. Chem. 279 (11): 9905–11. doi:10.1074/jbc.M310587200. PMID 14699103. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 


This article incorporates text from the United States National Library of Medicine, which is in the public domain.