Talk:List of drugs affected by grapefruit

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Contents

[edit] merge with Grapefruit juice

Grapefruit juice article really is all about drugs and their interaction with grapefruit juice, not anything else about the juice. Gzuckier 21:05, 22 November 2006 (UTC)

I agree, move Grapefruit juice to List of drugs affected by grapefruit. JKW 23:08, 2 January 2007 (UTC)

I'm with Gzukier -- keep this separate. I needed to use this list and I was glad to find it as a discrete article. This is really a pharmacological article -- grapefruit is only chosen because it contains certain chemicals. Notice that orange juice is mentioned at the bottom. Apollo 17:05, 12 January 2007 (UTC)

[edit] Solution to Grapefruit/Grapefruit juice/List of drugs affected by grapefruit

It seems like we have three articles on the same fundamental point - grapefruit juice acts on certain CYP enzymes.

I propose that we eliminate "grapefruit juice" and "list of drugs affected by grapefruit" entirely (redirect to grapefruit), since they revolve entirely around the CYP inhibition effect. Instead of those pages, we can have a brief note in the main grapefruit article about the CYP interactions. That way a reader can follow the link to CYP3A4 or whatever if they want specific information about that.

This way, people who want to know about grapefruits can get relevant information in the article. The article is about grapefruits, not about enzyme/drug interactions - a mere note that it will occur, a brief warning for consumers, and a link to the appropriate articles should suffice. CYP3A4 adequately covers the information expressed in grapefruit juice/list of drugs affected, and does so under a more appropriate title.

Any thoughts, suggestions? My primary concern is that we have multiple articles with the same information, and that we could condense this information and put it into more appropriate articles. 129.170.202.243 07:04, 17 January 2007 (UTC)

I think "List of affected drugs" is a useful article (bias: I initially created this page). I agree that this page and grapefruit juice overlap a lot, however. I think the article about CYP3A4 should discuss the enzyme and its function, and leave its interactions to this page. I will admit that this page isn't very useful if so incomplete. njaard 03:44, 20 January 2007 (UTC)

[edit] Bupropion interacts with grapefruit juice???

According to Micromedex, Wellbutrin package insert, and Lexi-comp, bupropion is metabolized mainly by CYP2B6. Lexi-comp mentions that CYP3A4 only plays a minor role in bupropion metabolism. Grapefruit juice is an inhibitor of CYP3A4. Therefore I think bupropion does NOT interact with grapefruit juice.

Reference [1] concluded that multiple doses of bupropion does NOT induce CYP2B6, CYP3A4, and CYP2E1 in human. It doesn't support a major interaction with grapefruit juice.

My suggestion would be removing buproprion from the list. —Preceding unsigned comment added by Jellen (talk • contribs) 05:56, 18 October 2007 (UTC)

[edit] Missing alot

You are missing alot of substances here, specifically most of the opiates. Tramadol, Oxycodone, Hydrocodone, etc. Plus Codeine interacts with grapefruit juice, but in this case it is weakened by grapefruit juice's CYP3A4 inhibition. —Preceding unsigned comment added by 68.8.17.27 (talk • contribs)


Thank you for your suggestion. When you feel an article needs improvement, please feel free to make those changes. Wikipedia is a wiki, so anyone can edit almost any article by simply following the edit this page link at the top. The Wikipedia community encourages you to be bold in updating pages. Don't worry too much about making honest mistakes — they're likely to be found and corrected quickly. If you're not sure how editing works, check out how to edit a page, or use the sandbox to try out your editing skills. New contributors are always welcome. You don't even need to log in (although there are many reasons why you might want to). WLU 17:18, 15 June 2007 (UTC)

The other thing I feel that's missing is a list of foods that exhibit the grapefruit effect. I know starfruit also does. I'd like to know if there were others. Potkettle 15:05, 20 July 2007 (UTC)

[edit] Rename

This page is more than just a list, it should probably be moved to Grapefruit-medication interaction or something similar. WLU 17:49, 16 August 2007 (UTC)

[edit] Inappropriate link

the following should be a reference, it's almost useless as a link and totally inappropriate. WLU (talk) 22:18, 2 January 2008 (UTC)

  • Arayne M, Sultana N, Bibi Z (2005). "Grape fruit juice-drug interactions.". Pak J Pharm Sci 18 (4): 45-57. PMID 16380358.