List of recombinant proteins
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Since human recombinants have replaced the animal version in human therapeutics, the prefix of "rh" for "human recombinant" appears less and less in the literature
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[edit] Human recombinants that largely replaced animal or harvested from human types
- Human growth hormone (rhGH) Humatrope from Lilly and Serostim from Serono replaced cadaver harvested human growth hormone
- Human insulin (rhI) Humulin from Lilly and Novolin from Novo Nordisk among others; largely replaced bovine and porcine insulin for human therapy. Some prefer to continue using the animal-sourced preparations, as there is some evidence that synthetic insulin varieties are more likely to induce hypoglycemia unawareness. Remaining manufacturers of highly-purified animal-sourced insulin include Poland's Polfa Tarchomin S.A., Argentina's Laboratorios Beta S.A., and China's Wanbang Biopharma Co.
- Follicle-stimulating hormone FSH replaced Serono's Pergonal which was previously isolated from post-menopausal female urine
- Factor VIII Kogenate from Bayer replaced blood harvested factor VIII
[edit] Human recombinants with recombination as only source
- Erythropoietin (EPO) Epogen from Amgen
- Granulocyte colony-stimulating factor (G-CSF) filgrastim sold as Neupogen from Amgen; pegfilgrastim sold as Neulasta
- alpha-glactosidase A Fabrazyme by Genzyme
- alpha-L-iduronidase (rhIDU; laronidase) Aldurazyme by BioMarin Pharmaceutical and Genzyme
- N-acetylgalactosamine-4-sulfatase (rhASB; galsulfase) Naglazyme (TM) by BioMarin Pharmaceutical
- DNAse Pulmozyme by Genentech
- Tissue plasminogen activator (TPA) Activase by Genentech
- Glucocerebrosidase Ceredase by Genzyme
- Interferon (IF) Interferon-beta-1a as Avonex from Biogen Idec; Rebif from Serono; Interferon beta-1b as Betaseron from Schering
- Insulin-like growth factor 1 (IGF-1)
[edit] Animal recombinants
- Bovine somatotropin (bST)
- Porcine somatotropin (pST)
- Bovine Chymosin
[edit] Viral recombinants
- Envelope protein of the hepatitis B virus marketed as Engerix-B by SmithKline Beecham