Talk:Lipoic acid
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Article Grading: The following comments were left by the quality and importance raters: (edit · history · watch · refresh) <<Very large doses of 6,8-dithiooctanoic acid are themselves toxic. The lowest reported dosage to exhibit toxic side-effects (TDLo) was 0.83 mg/kg (total dose less than 1/20 gram). The oral LD50 for experimental rodents was found to be between 500 and 1000 mg/kg.>> A citation here is very important. What are the toxic side effects noted? It is somewhat misleading to change the naming of the compound - most readers will not recognize that lipoic acid and 6,8-dithiooctanoic acid are synonomous. Thus there is a problem with objectivity here. People should be furnished with the best information to allow themselves to make their own informed risk-benefit decisions, and especially choose the dose which offers the best benefit/risk, if they choose to use supplements. Please note for instance: Jarrow sells ALA with recommended dose 100 mg, which for an 'average' person is ~2 mg/kg - above the toxic side effect dose (0.83 mg/kg) noted here. Aranck 14:22, 8 April 2007 (UTC) |
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Article Grading: The following comments were left by the quality and importance raters: (edit · history · refresh · how to use this template) <<Very large doses of 6,8-dithiooctanoic acid are themselves toxic. The lowest reported dosage to exhibit toxic side-effects (TDLo) was 0.83 mg/kg (total dose less than 1/20 gram). The oral LD50 for experimental rodents was found to be between 500 and 1000 mg/kg.>> A citation here is very important. What are the toxic side effects noted? It is somewhat misleading to change the naming of the compound - most readers will not recognize that lipoic acid and 6,8-dithiooctanoic acid are synonomous. Thus there is a problem with objectivity here. People should be furnished with the best information to allow themselves to make their own informed risk-benefit decisions, and especially choose the dose which offers the best benefit/risk, if they choose to use supplements. Please note for instance: Jarrow sells ALA with recommended dose 100 mg, which for an 'average' person is ~2 mg/kg - above the toxic side effect dose (0.83 mg/kg) noted here. Aranck 14:22, 8 April 2007 (UTC) |
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dihydrolipoic acid structure incorrect, missing a carbon...
- Fixed. Sorry. Ben 11:04, 21 December 2006 (UTC)
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[edit] Quote from Article
Dihydrolipoic acid is able to regenerate (reduce) antioxidants
Huh? to whomever contributed the above; beg, borrow, or steal a dictionary please!
Regenerate does not mean reduce, it means; Biology: to renew or restore (a lost, removed, or injured part).
Lipoate is know to have a protective role in maintaining glutathione levels —Preceding unsigned comment added by 59.167.170.232 (talk) 00:52, 19 December 2007 (UTC)
[edit] R LIPOIC ACID or thioctic acid
I've had arthritis for 30 years and I was on anti-inflammatories. I tried R Lipoic Acid and to my biggest surprise I could suddenly move my fingers in the morning without real pain and no longer have leg syndrome at night. I no longer use anti-inflammatories and swear by this supplement. My husband, who is diabetic, has now started this supplement. User Suzanne LeBlanc January 2, 2006
[edit] Chelation therapy
Chelation therapy is certainly not the primary use of Lipoic acid! Lipoic acid is a very popular antioxidant supplement. While highly pushed by many people interested in taking nutritional supplements, its primarily weakness is the fact that its half-life is only about 20 minutes. Its extremely short half-life is what makes it ineffective to take as a supplement in anything other than a timed-released form.
Next on the gripe list, is the fact that many people believe that only the expensive R version is effective, while the L version is the form most commonly sold by vitamin suppliers.
This is another glaring example, of the mickey mouse coverage of articles in Wikipedia. -- John Gohde 02:41, 10 Apr 2005 (UTC)
The half life is more like 3 hours, and should be a consideration in a low dose oral chelation protocol. Mercury toxic individuals can experience adverse reactions if this is not respected or with inappropriate doses. If the label doesn't say it's the R- form, then its manufactured as a racemic mixture. SomeNumpty 13:39, 10 October 2006 (UTC)
[edit] Question Regarding Chelation
The article currently reads:
- Neither DMSA nor MSM can cross the blood-brain barrier, which is why both lipoic acid and DMSA are used
But can MSM and Alpha Lipoic Acid be to remove mercury from the brain and body? I would think so given the context, but the information is not explicitly laid out in the article. Can anyone clarify? --Deepstratagem 08:48, 26 January 2006 (UTC)
Response to above "Question Regarding Chelation" Where did you get this information? There are a vast number of research articles written that state the exact opposite. -That DMSA and MSM do, infact cross the BB barrier. Kindly google this for yourself. Not to be confused with DMPS which is noted to be ineffective in crossing BB barrier. If you are looking for specific info regarding mercury removal from brain, study the ALA-DMSA protocol from Andy Cutler. [User:Cageykay] 3/26/06
- You obviously didn't take the time to read my question. I got the information from the current article, and I'm asking whether it is accurate. The question is whether MSM can be used in combination with ALA to remove mercury from the brain and body. Are you going to answer it, or patronize me? --Deepstratagem 22:20, 26 March 2006 (UTC)
Deepstratagem, I read your question. Calm down, and tell me - are you quoting the "Lipoic Acid Article" itself? Or, could this possibly be from another article? I did state where you could look to get your answer. It will be detailed reading, but if it is not clear, then I invite you to e-mail me. Would be pleased to discuss further, Let's not continue wasting valauble space on Wikipedia. BTW, Deepstratagem, it's not my intent patronize you. Please don't take it as such. [User: CageyKay] 3/27/06
- No problem. I thought I was clear in that the article in reference was the one corresponding to this discussion page. But it's not a waste to discuss it in Wikipedia if we are succint and it is related to the article; that way the article can be further improved. --Deepstratagem 08:52, 30 March 2006 (UTC)
I have removed the section of the article with the original quote cited above by Deepstrategem, sorry for any confusion. It is documented by four studies that MSM crosses the blood-brain barrier, so the article was incorrect (see MSM article). As to the question originally posed, after extensive review of the literature on MSM I have not come across any description of its use for removal of mercury, though I couldn't say that it is unable to do so. Prithason 01:00, 28 March 2006 (UTC)
[edit] dermatological applications
apparently it's a hot new thing in skin treatments. anyone knowledgable want to take a whack at that in the article? tej 14:09, 6 March 2006 (UTC)
[edit] Missing subjects?
- what is the natural source of Lipoic Acid?
- what are its traditional uses if any?
- why is it in skin care products like the Skin Eternal range from Source Naturals?
User: ceirius; 24 Aug'06 (moved down by Dirk Beetstra T C 07:24, 24 August 2006 (UTC), Ceirius, please use ~~~~ to sign your posts to talk pages)
[edit] Is it alpha-lipoic acid or alpha lipoic acid?
Is there an established 'correct' word form for alpha-lipoic acid? Both forms – alpha-lipoic acid and alpha lipoic acid – are used in the article and in the quoted references. Nunquam Dormio 17:22, 2 October 2007 (UTC)
[edit] Lipoic acid crosses the BBB barrier
I have added a reference supporting the fact that lipoic acid crosses the BBB barrier and the cell membrane. --Juliusllb 00:12, 12 February 2008 (UTC)
[edit] Lipoic acid as a chelator
Assertion on the greater effectiveness of DMSA and DMPS as chelators has been removed because of the lack of references. I have added the fact that DMSA and DMPS cannot cross the BBB supported by two new references. I have also moved all this stuff to a new section on the possible use of lipoic acid as a chelator.--Juliusllb 20:28, 4 March 2008 (UTC)
