Lipopolysaccharide glucosyltransferase I

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In enzymology, a lipopolysaccharide glucosyltransferase I (EC 2.4.1.58) is an enzyme that catalyzes the chemical reaction

UDP-glucose + lipopolysaccharide $\rightleftharpoons$ UDP + D-glucosyl-lipopolysaccharide

Thus, the two substrates of this enzyme are UDP-glucose and lipopolysaccharide, whereas its two products are UDP and D-glucosyl-lipopolysaccharide.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-glucose:lipopolysaccharide glucosyltransferase. Other names in common use include UDP-glucose:lipopolysaccharide glucosyltransferase I, lipopolysaccharide glucosyltransferase, uridine diphosphate glucose:lipopolysaccharide glucosyltransferase, I, and uridine diphosphoglucose-lipopolysaccharide glucosyltransferase. This enzyme participates in lipopolysaccharide biosynthesis and glycan structures - biosynthesis 2.

[edit] References

IUBMB entry for 2.4.1.58
BRENDA references for 2.4.1.58 (Recommended.)
PubMed references for 2.4.1.58
PubMed Central references for 2.4.1.58
Google Scholar references for 2.4.1.58
Muller E, Hinckley A, Rothfield L (1972). "Studies of phospholipid-requiring bacterial enzymes. 3. Purification and properties of uridine diphosphate glucose:lipopolysaccharide glucosyltransferase I". J. Biol. Chem. 247: 2614–22. PMID 4553445.
Rothfield L, Osborn MJ and Horecker BL (1964). "Biosynthesis of bacterial lipopolysaccharide. II. Incorporation of glucose and galactose catalyzed by particulate and soluble enzymes in salmonella". J. Biol. Chem. 239: 2788–2795.