LIPH

From Wikipedia, the free encyclopedia


Lipase, member H
Identifiers
Symbol(s) LIPH; PLA1B; mPA-PLA1; mPA-PLA1 alpha
External IDs OMIM: 607365 MGI: 2388029 HomoloGene: 71802
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 200879 239759
Ensembl ENSG00000163898 ENSMUSG00000044626
Uniprot Q8WWY8 Q8CIV3
Refseq NM_139248 (mRNA)
NP_640341 (protein)		 NM_153404 (mRNA)
NP_700453 (protein)
Location Chr 3: 186.71 - 186.75 Mb Chr 16: 21.87 - 21.9 Mb
Pubmed search [1] [2]

Lipase, member H, also known as LIPH, is a human gene.[1]

This gene encodes a membrane-bound member of the mammalian triglyceride lipase family. It catalyzes the production of 2-acyl lysophosphatidic acid (LPA), which is a lipid mediator with diverse biological properties that include platelet aggregation, smooth muscle contraction, and stimulation of cell proliferation and motility.[1]

[edit] References

  1. ^ a b Entrez Gene: LIPH lipase, member H.

[edit] Further reading

  • Sonoda H, Aoki J, Hiramatsu T, et al. (2002). "A novel phosphatidic acid-selective phospholipase A1 that produces lysophosphatidic acid.". J. Biol. Chem. 277 (37): 34254–63. doi:10.1074/jbc.M201659200. PMID 12063250. 
  • Jin W, Broedl UC, Monajemi H, et al. (2003). "Lipase H, a new member of the triglyceride lipase family synthesized by the intestine.". Genomics 80 (3): 268–73. PMID 12213196. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Wen XY, Hegele RA, Wang J, et al. (2004). "Identification of a novel lipase gene mutated in lpd mice with hypertriglyceridemia and associated with dyslipidemia in humans.". Hum. Mol. Genet. 12 (10): 1131–43. PMID 12719377. 
  • Hiramatsu T, Sonoda H, Takanezawa Y, et al. (2004). "Biochemical and molecular characterization of two phosphatidic acid-selective phospholipase A1s, mPA-PLA1alpha and mPA-PLA1beta.". J. Biol. Chem. 278 (49): 49438–47. doi:10.1074/jbc.M213018200. PMID 12963729. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Aslam M, Chahrour MH, Razzaq A, et al. (2005). "A novel locus for autosomal recessive form of hypotrichosis maps to chromosome 3q26.33-q27.3.". J. Med. Genet. 41 (11): 849–52. doi:10.1136/jmg.2004.019729. PMID 15520410. 
  • Kazantseva A, Goltsov A, Zinchenko R, et al. (2006). "Human hair growth deficiency is linked to a genetic defect in the phospholipase gene LIPH.". Science 314 (5801): 982–5. doi:10.1126/science.1133276. PMID 17095700. 
  • Ali G, Chishti MS, Raza SI, et al. (2007). "A mutation in the lipase H (LIPH) gene underlie autosomal recessive hypotrichosis.". Hum. Genet. 121 (3-4): 319–25. doi:10.1007/s00439-007-0344-0. PMID 17333281. 
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