LINGO1

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Leucine rich repeat and Ig domain containing 1
PDB rendering based on 2id5.
Available structures: 2id5
Identifiers
Symbol(s) LINGO1; FLJ14594; LERN1; LRRN6A; MGC17422; UNQ201
External IDs OMIM: 609791 MGI: 1915522 HomoloGene: 41891
Orthologs
Human Mouse
Entrez 84894 235402
Ensembl ENSG00000169783 ENSMUSG00000049556
Refseq NM_032808 (mRNA)
NP_116197 (protein)		 XM_974866 (mRNA)
XP_979960 (protein)
Location Chr 15: 75.69 - 75.7 Mb Chr 9: 56.42 - 56.48 Mb
Pubmed search [1] [2]

Leucine rich repeat and Ig domain containing 1, also known as LINGO1, is a human gene.[1]


[edit] References

  1. ^ Entrez Gene: LINGO1 leucine rich repeat and Ig domain containing 1.

[edit] Further reading

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309. 
  • Carim-Todd L, Escarceller M, Estivill X, Sumoy L (2004). "LRRN6A/LERN1 (leucine-rich repeat neuronal protein 1), a novel gene with enriched expression in limbic system and neocortex.". Eur. J. Neurosci. 18 (12): 3167-82. PMID 14686891. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Mi S, Lee X, Shao Z, et al. (2004). "LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex.". Nat. Neurosci. 7 (3): 221-8. doi:10.1038/nn1188. PMID 14966521. 
  • Shao Z, Browning JL, Lee X, et al. (2005). "TAJ/TROY, an orphan TNF receptor family member, binds Nogo-66 receptor 1 and regulates axonal regeneration.". Neuron 45 (3): 353-9. doi:10.1016/j.neuron.2004.12.050. PMID 15694322. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514. 
  • Mosyak L, Wood A, Dwyer B, et al. (2007). "The structure of the Lingo-1 ectodomain, a module implicated in central nervous system repair inhibition.". J. Biol. Chem. 281 (47): 36378-90. doi:10.1074/jbc.M607314200. PMID 17005555. 
  • Satoh J, Tabunoki H, Yamamura T, et al. (2007). "TROY and LINGO-1 expression in astrocytes and macrophages/microglia in multiple sclerosis lesions.". Neuropathol. Appl. Neurobiol. 33 (1): 99-107. doi:10.1111/j.1365-2990.2006.00787.x. PMID 17239012. 
  • Inoue H, Lin L, Lee X, et al. (2007). "Inhibition of the leucine-rich repeat protein LINGO-1 enhances survival, structure, and function of dopaminergic neurons in Parkinson's disease models.". Proc. Natl. Acad. Sci. U.S.A. 104 (36): 14430-5. doi:10.1073/pnas.0700901104. PMID 17726113. 
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