LIME1

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Lck interacting transmembrane adaptor 1
Identifiers
Symbol(s) LIME1; FLJ20406; LIME; LP8067; dJ583P15.4
External IDs OMIM: 609809 MGI: 1919949 HomoloGene: 56785
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 54923 72699
Ensembl ENSG00000203896 n/a
Uniprot Q9H400 n/a
Refseq NM_017806 (mRNA)
NP_060276 (protein)		 NM_023684 (mRNA)
NP_076173 (protein)
Location Chr 20: 61.84 - 61.84 Mb n/a
Pubmed search [1] [2]

Lck interacting transmembrane adaptor 1, also known as LIME1, is a human gene.[1]

LIME1 is a raft-associated transmembrane adaptor phosphoprotein that is preferentially expressed in hemopoietic cells, particularly T cells (Brdickova et al., 2003; Hur et al., 2003).[supplied by OMIM][1]

[edit] References

  1. ^ a b Entrez Gene: LIME1 Lck interacting transmembrane adaptor 1.

[edit] Further reading

  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Hur EM, Son M, Lee OH, et al. (2004). "LIME, a novel transmembrane adaptor protein, associates with p56lck and mediates T cell activation.". J. Exp. Med. 198 (10): 1463–73. doi:10.1084/jem.20030232. PMID 14610044. 
  • Brdicková N, Brdicka T, Angelisová P, et al. (2004). "LIME: a new membrane Raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling.". J. Exp. Med. 198 (10): 1453–62. doi:10.1084/jem.20031484. PMID 14610046. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Suzuki Y, Yamashita R, Shirota M, et al. (2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.". Genome Res. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMID 15342556. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Wan D, Gong Y, Qin W, et al. (2004). "Large-scale cDNA transfection screening for genes related to cancer development and progression.". Proc. Natl. Acad. Sci. U.S.A. 101 (44): 15724–9. doi:10.1073/pnas.0404089101. PMID 15498874. 
  • Tedoldi S, Paterson JC, Hansmann ML, et al. (2006). "Transmembrane adaptor molecules: a new category of lymphoid-cell markers.". Blood 107 (1): 213–21. doi:10.1182/blood-2005-06-2273. PMID 16160011. 
  • Ahn E, Lee H, Yun Y (2006). "LIME acts as a transmembrane adapter mediating BCR-dependent B-cell activation.". Blood 107 (4): 1521–7. doi:10.1182/blood-2005-05-1859. PMID 16249387. 
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