Licodione synthase

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In enzymology, a licodione synthase (EC 1.14.13.87) is an enzyme that catalyzes the chemical reaction

liquiritigenin + NADPH + H⁺ + O₂ $\rightleftharpoons$ licodione + NADP⁺ + H₂O

The 4 substrates of this enzyme are liquiritigenin, NADPH, H⁺, and O₂, whereas its 3 products are licodione, NADP⁺, and H₂O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is liquiritigenin,NADPH:oxygen oxidoreductase (licodione-forming).

[edit] References

IUBMB entry for 1.14.13.87
BRENDA references for 1.14.13.87 (Recommended.)
PubMed references for 1.14.13.87
PubMed Central references for 1.14.13.87
Google Scholar references for 1.14.13.87
Otani K, Takahashi T, Furuya T, Ayabe S (1994). "Licodione Synthase, a Cytochrome P450 Monooxygenase Catalyzing 2-Hydroxylation of 5-Deoxyflavanone, in Cultured Glycyrrhiza echinata L. Cells". Plant. Physiol. 105: 1427–1432. PMID 12232298.
Akashi T, Aoki T, Ayabe S (1998). "Identification of a cytochrome P450 cDNA encoding (2S)-flavanone 2-hydroxylase of licorice (Glycyrrhiza echinata L.; Fabaceae) which represents licodione synthase and flavone synthase II". FEBS. Lett. 431: 287–90. doi:10.1016/S0014-5793(98)00781-9. PMID 9708921.