LHX6

From Wikipedia, the free encyclopedia

LIM homeobox 6

Identifiers

LHX6; LHX6.1; MGC119542; MGC119544; MGC119545

External IDs

OMIM: 608215 MGI: 1306803 HomoloGene: 7401

Gene ontology
Molecular Function:	• transcription factor activity • zinc ion binding • sequence-specific DNA binding • metal ion binding
Cellular Component:	• nucleus
Biological Process:	• regulation of transcription, DNA-dependent • brain development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014368 (mRNA)
NP_055183 (protein)

NM_008500 (mRNA)
NP_032526 (protein)

Location

Chr 9: 124 - 124.03 Mb

Chr 2: 35.91 - 35.93 Mb

Pubmed search

[1]

[2]

LIM homeobox 6, also known as LHX6, is a human gene.^[1]

This gene encodes a member of a large protein family that contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and may be involved in the control of differentiation and development of neural and lymphoid cells. Two alternatively spliced transcript variants encoding distinct isoforms have been described for this gene. Alternatively spliced transcript variants have been identified, but their biological validity has not been determined.^[1]

[edit] References

^ ^a ^b Entrez Gene: LHX6 LIM homeobox 6.

[edit] Further reading

Kimura N, Ueno M, Nakashima K, Taga T (1999). "A brain region-specific gene product Lhx6.1 interacts with Ldb1 through tandem LIM-domains.". J. Biochem. 126 (1): 180–7. PMID 10393337.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788–95. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. doi:10.1038/nature02465. PMID 15164053.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMID 15489336.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMID 16381901.
Estécio MR, Youssef EM, Rahal P, et al. (2006). "LHX6 is a sensitive methylation marker in head and neck carcinomas.". Oncogene 25 (36): 5018–26. doi:10.1038/sj.onc.1209509. PMID 16732332.