LHX1

From Wikipedia, the free encyclopedia

LIM homeobox 1

Identifiers

LHX1; LIM-1; LIM1; MGC126723; MGC138141

External IDs

OMIM: 601999 MGI: 99783 HomoloGene: 4068

Gene ontology
Molecular Function:	• transcription factor activity • RNA polymerase II transcription factor activity • protein binding • zinc ion binding • sequence-specific DNA binding • metal ion binding
Cellular Component:	• nucleus
Biological Process:	• endoderm formation • regulation of transcription, DNA-dependent • nervous system development • organ morphogenesis • gastrulation (sensu Mammalia)

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005568 (mRNA)
NP_005559 (protein)

NM_008498 (mRNA)
NP_032524 (protein)

Location

Chr 17: 32.37 - 32.37 Mb

Chr 11: 84.33 - 84.34 Mb

Pubmed search

[1]

[2]

LIM homeobox 1, also known as LHX1, is a human gene.^[1]

This gene encodes a member of a large protein family which contains the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator and be involved in control of differentiation and development of neural and lymphoid cells. A similar protein in mice is an essential regulator of the vertebrate head organizer.^[1]

[edit] References

^ ^a ^b Entrez Gene: LHX1 LIM homeobox 1.

[edit] Further reading

Shawlot W, Behringer RR (1995). "Requirement for Lim1 in head-organizer function.". Nature 374 (6521): 425-30. doi:10.1038/374425a0. PMID 7700351.
Bozzi F, Bertuzzi S, Strina D, et al. (1997). "The exon-intron structure of human LHX1 gene.". Biochem. Biophys. Res. Commun. 229 (2): 494-7. doi:10.1006/bbrc.1996.1832. PMID 8954926.
Dong WF, Heng HH, Lowsky R, et al. (1997). "Cloning, expression, and chromosomal localization to 11p12-13 of a human LIM/HOMEOBOX gene, hLim-1.". DNA Cell Biol. 16 (6): 671-8. PMID 9212161.
Jurata LW, Pfaff SL, Gill GN (1998). "The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors.". J. Biol. Chem. 273 (6): 3152-7. PMID 9452425.
Ostendorff HP, Peirano RI, Peters MA, et al. (2002). "Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors.". Nature 416 (6876): 99-103. doi:10.1038/416099a. PMID 11882901.
Phillips JC (2003). "Assignment of LHX1 to human chromosome bands 17q11.2-->q12 by use of radiation hybrid mapping and somatic cell hybridization.". Cytogenet. Genome Res. 97 (1-2): 140D. doi:10.1159/000064048. PMID 12438757.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Zody MC, Garber M, Adams DJ, et al. (2006). "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.". Nature 440 (7087): 1045-9. doi:10.1038/nature04689. PMID 16625196.