LGTN

From Wikipedia, the free encyclopedia


Ligatin
Identifiers
Symbol(s) LGTN; HCA56
External IDs OMIM: 151625 MGI109342 HomoloGene38244
RNA expression pattern

More reference expression data

Orthologs
Human Mouse
Entrez 1939 16865
Ensembl ENSG00000143486 ENSMUSG00000026427
Uniprot P41214 Q61211
Refseq NM_006893 (mRNA)
NP_008824 (protein)
XM_976282 (mRNA)
XP_981376 (protein)
Location Chr 1: 204.83 - 204.85 Mb Chr 1: 132.98 - 133.01 Mb
Pubmed search [1] [2]

Ligatin, also known as LGTN, is a human gene.[1]

This gene encodes a protein receptor that localizes phosphoglycoproteins within endosomes and at the cell periphery. This trafficking receptor for phosphoglycoproteins may play a role in neuroplasticity by modulating cell-cell interactions, intracellular adhesion, and protein binding at membrane surfaces. In hippocampal neurons, long-lasting down-regulation of ligatin mRNA levels occurs via post-transcriptional RNA processing following glutamate receptor activation. This protein contains single PUA and SUI1 domains and these domains may function in RNA binding and translation initiation, respectively.[1]

[edit] References

[edit] Further reading

  • Jakoi ER, Brown AL, Ho YS, Snyderman R (1990). "Molecular cloning of the cDNA for ligatin.". J. Cell. Sci. 93 ( Pt 2): 227–32. PMID 2482295. 
  • Jakoi ER, Ross PE, Ping Ting-Beall H, et al. (1987). "Ligatin: a peripheral membrane protein with covalently bound palmitic acid.". J. Biol. Chem. 262 (3): 1300–4. PMID 3805022. 
  • Gaston SM, Marchase RB, Jakoi ER (1982). "Brain ligatin: a membrane lectin that binds acetylcholinesterase.". J. Cell. Biochem. 18 (4): 447–59. doi:10.1002/jcb.1982.240180406. PMID 7085778. 
  • Marchase RB, Koro LA, Kelly CM, McClay DR (1982). "A possible role for ligatin and the phosphoglycoproteins it binds in calcium-dependent retinal cell adhesion.". J. Cell. Biochem. 18 (4): 461–8. doi:10.1002/jcb.1982.240180407. PMID 7085779. 
  • Jakoi ER, Kempe K, Gaston SM (1982). "Ligatin binds phosphohexose residues on acidic hydrolases.". Journal of supramolecular structure and cellular biochemistry 16 (2): 139–53. doi:10.1002/jsscb.1981.380160205. PMID 7299841. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Wang Y, Han KJ, Pang XW, et al. (2002). "Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies.". J. Immunol. 169 (2): 1102–9. PMID 12097419. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935. 
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.