LGALS2

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Lectin, galactoside-binding, soluble, 2
PDB rendering based on 1hlc.
Available structures: 1hlc
Identifiers
Symbol(s) LGALS2; HL14; MGC75071
External IDs OMIM: 150571 MGI: 895068 HomoloGene: 4741
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 3957 107753
Ensembl ENSG00000100079 ENSMUSG00000043501
Uniprot P05162 Q8K1I1
Refseq NM_006498 (mRNA)
NP_006489 (protein)		 XM_001000934 (mRNA)
XP_001000934 (protein)
Location Chr 22: 36.3 - 36.31 Mb Chr 15: 78.68 - 78.68 Mb
Pubmed search [1] [2]

Lectin, galactoside-binding, soluble, 2, also known as LGALS2, is a human gene.[1]

The protein encoded by this gene is a soluble beta-galactoside binding lectin. The encoded protein is found as a homodimer and can bind to lymphotoxin-alpha. A single nucleotide polymorphism in an intron of this gene can alter the transcriptional level of the protein, with a resultant increased risk of myocardial infarction.[1]

[edit] References

  1. ^ a b Entrez Gene: LGALS2 lectin, galactoside-binding, soluble, 2.

[edit] Further reading

  • Gitt MA, Massa SM, Leffler H, Barondes SH (1992). "Isolation and expression of a gene encoding L-14-II, a new human soluble lactose-binding lectin.". J. Biol. Chem. 267 (15): 10601-6. PMID 1375225. 
  • Gitt MA, Barondes SH (1991). "Genomic sequence and organization of two members of a human lectin gene family.". Biochemistry 30 (1): 82-9. PMID 1988031. 
  • Gitt MA, Barondes SH (1986). "Evidence that a human soluble beta-galactoside-binding lectin is encoded by a family of genes.". Proc. Natl. Acad. Sci. U.S.A. 83 (20): 7603-7. PMID 3020551. 
  • Lobsanov YD, Gitt MA, Leffler H, et al. (1994). "X-ray crystal structure of the human dimeric S-Lac lectin, L-14-II, in complex with lactose at 2.9-A resolution.". J. Biol. Chem. 268 (36): 27034-8. PMID 8262940. 
  • Lobsanov YD, Gitt MA, Leffler H, et al. (1993). "Crystallization and preliminary X-ray diffraction analysis of the human dimeric S-Lac lectin (L-14-II).". J. Mol. Biol. 233 (3): 553-5. doi:10.1006/jmbi.1993.1533. PMID 8411163. 
  • Mehrabian M, Gitt MA, Sparkes RS, et al. (1993). "Two members of the S-lac lectin gene family, LGALS1 and LGALS2, reside in close proximity on human chromosome 22q12-q13.". Genomics 15 (2): 418-20. doi:10.1006/geno.1993.1078. PMID 8449510. 
  • Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489-95. doi:10.1038/990031. PMID 10591208. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ozaki K, Inoue K, Sato H, et al. (2004). "Functional variation in LGALS2 confers risk of myocardial infarction and regulates lymphotoxin-alpha secretion in vitro.". Nature 429 (6987): 72-5. doi:10.1038/nature02502. PMID 15129282. 
  • Sturm A, Lensch M, André S, et al. (2004). "Human galectin-2: novel inducer of T cell apoptosis with distinct profile of caspase activation.". J. Immunol. 173 (6): 3825-37. PMID 15356130. 
  • Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome.". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMID 15461802. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Christensen MB, Lawlor DA, Gaunt TR, et al. (2006). "Genotype of galectin 2 (LGALS2) is associated with insulin-glucose profile in the British Women's Heart and Health Study.". Diabetologia 49 (4): 673-7. doi:10.1007/s00125-006-0145-3. PMID 16468038. 
  • Stowell SR, Karmakar S, Stowell CJ, et al. (2007). "Human galectin-1, -2, and -4 induce surface exposure of phosphatidylserine in activated human neutrophils but not in activated T cells.". Blood 109 (1): 219-27. doi:10.1182/blood-2006-03-007153. PMID 16940423. 
  • Mangino M, Braund P, Singh R, et al. (2007). "LGALS2 functional variant rs7291467 is not associated with susceptibility to myocardial infarction in Caucasians.". Atherosclerosis 194 (1): 112-5. doi:10.1016/j.atherosclerosis.2006.10.004. PMID 17098239. 
  • Kimura A, Takahashi M, Choi BY, et al. (2007). "Lack of association between LTA and LGALS2 polymorphisms and myocardial infarction in Japanese and Korean populations.". Tissue Antigens 69 (3): 265-9. doi:10.1111/j.1399-0039.2006.00798.x. PMID 17493152. 
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