Talk:Levomepromazine

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[edit] Sedative neuroleptic non plus ultra.

I just wanted to mention that levomepromazine is considered by the most experts known to me to be the most sedative neuroleptic among all. In a sedative/neuroleptic-naive patient, doses as low as 2,5 - 7,5 mg orally are so strongly sedative, that it can be used as hypnotic, or rather hypnagogic.--84.163.87.66 08:10, 28 April 2007 (UTC)

[edit] Structure/stereochemistry.

I would also like to stress, that the drug levomepromazine is a pure enantiomer, as the name already suggests: it is the (R)-enantiomer of the racemate mepromazine (formerly the L-isomer, hence the name levomepromazine). The structure and IUPAC name of the compound in the drugbox are those of the racemic mepromazine; correct IUPAC name of levomepromazine is (R)-, or (2R)-3-(2-Methoxyphenothiazine-10-yl-)-N,N,2-trimethylpropanamine. Structure can be seen here:
http://img207.imageshack.us/img207/830/levomepromazinepl5.png
Usually, oral tablets of levomepromazine contain the drug as hydrogenmaleate salt, liquid galenics (such as drops/oral solution/syrup and injections) contain the levomepromazine as hydrochloride salt.--84.163.87.66 08:42, 28 April 2007 (UTC)