Leukotriene B4

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Leukotriene B4
Identifiers
CAS number [71160-24-2]
PubChem 169
MeSH Leukotriene+B4
Properties
Molecular formula C20H32O4
Molar mass 336.466
Except where noted otherwise, data are given for
materials in their standard state
(at 25 °C, 100 kPa)
Infobox disclaimer and references

Leukotriene B4 is a leukotriene involved in inflammation. It is produced from leukocytes in response to inflammatory mediators and is able to induce the adhesion and activation of leukocytes on the endothelium, allowing them to bind to and cross it into the tissue[1]. In neutrophils, it is also a potent chemoattractant, and is able to induce the formation of reactive oxygen species and the release of lysosome enzymes by these cells[1].

Eicosanoid synthesis. (Leukotrienes at right.)
Eicosanoid synthesis. (Leukotrienes at right.)

[edit] References

  1. ^ a b Cotran; Kumar, Collins. Robbins Pathologic Basis of Disease. Philadelphia: W.B Saunders Company. 0-7216-7335-X. 
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Autacoids, unsaturated fatty acids: Eicosanoids
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