Leukotriene-C4 synthase

From Wikipedia, the free encyclopedia

In enzymology, a leukotriene-C4 synthase (EC 4.4.1.20) is an enzyme that catalyzes the chemical reaction

leukotriene C₄ $\rightleftharpoons$ leukotriene A₄ + glutathione

Hence, this enzyme has one substrate, leukotriene C4, and two products, leukotriene A4 and glutathione.

This enzyme belongs to the family of lyases, specifically the class of carbon-sulfur lyases. The systematic name of this enzyme class is leukotriene-C4 glutathione-lyase (leukotriene-A4-forming). Other names in common use include leukotriene C4 synthetase, LTC4 synthase, LTC4 synthetase, leukotriene A4:glutathione S-leukotrienyltransferase, (7E,9E,11Z,14Z)-(5S,6R)-5,6-epoxyicosa-7,9,11,14-, tetraenoate:glutathione leukotriene-transferase, (epoxide-ring-opening), (7E,9E,11Z,14Z)-(5S,6R)-6-(glutathion-S-yl)-5-hydroxyicosa-, and 7,9,11,14-tetraenoate glutathione-lyase (epoxide-forming). This enzyme participates in arachidonic acid metabolism.

1 Structural studies
2 References
3 External links
- 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 2PNO, 2UUH, and 2UUI.

[edit] References

IUBMB entry for 4.4.1.20
BRENDA references for 4.4.1.20 (Recommended.)
PubMed references for 4.4.1.20
PubMed Central references for 4.4.1.20
Google Scholar references for 4.4.1.20
Bach MK, Brashler JR, Morton DR Jr (1984). "Solubilization and characterization of the leukotriene C4 synthetase of rat basophil leukemia cells: a novel, particulate glutathione S-transferase". Arch. Biochem. Biophys. 230: 455–65. doi:10.1016/0003-9861(84)90426-0. PMID 6324687.
Shimizu T (1988). "Enzymes functional in the syntheses of leukotrienes and related compounds". Int. J. Biochem. 20: 661–6. doi:10.1016/0020-711X(88)90160-7. PMID 2846379.
Lam BK, Austen KF (2002). "Leukotriene C4 synthase: a pivotal enzyme in cellular biosynthesis of the cysteinyl leukotrienes". Prostaglandins. Other. Lipid. Mediat. 68-69: 511–20. doi:10.1016/S0090-6980(02)00052-7. PMID 12432940.
Christmas P, Weber BM, McKee M, Brown D, Soberman RJ (2002). "Membrane localization and topology of leukotriene C4 synthase". J. Biol. Chem. 277: 28902–8. doi:10.1074/jbc.M203074200. PMID 12023288.