Leucine 2,3-aminomutase

From Wikipedia, the free encyclopedia

In enzymology, a leucine 2,3-aminomutase (EC 5.4.3.7) is an enzyme that catalyzes the chemical reaction

(2S)-alpha-leucine (3R)-beta-leucine

Hence, this enzyme has one substrate, (2S)-alpha-leucine, and one product, (3R)-beta-leucine.

This enzyme belongs to the family of isomerases, specifically those intramolecular transferases transferring amino groups. The systematic name of this enzyme class is (2S)-alpha-leucine 2,3-aminomutase. This enzyme participates in valine, leucine and isoleucine degradation. It employs one cofactor, cobamide.

[edit] References

• IUBMB entry for 5.4.3.7
• BRENDA references for 5.4.3.7 (Recommended.)
• PubMed references for 5.4.3.7
• PubMed Central references for 5.4.3.7
• Google Scholar references for 5.4.3.7
• Freer I, Pedrocchi-Fantoni G, Picken DJ and Overton KH (1981). "Stereochemistry of the leucine 2,3-aminomutase from tissue-cultures of Andrographis paniculata". J. Chem. Soc. Chem. Commun.: 80–82. 
• Poston JM (1976). "Leucine 2,3-aminomutase, an enzyme of leucine catabolism". J. Biol. Chem. 251: 1859–63. PMID 1270414. 
• Poston JM (1976). "Coenzyme B12-dependent enzymes in potatoes: leucine 2,3-aminomutase and methylmalonyl-CoA mutase". Phytochemistry 17: 401–402. doi:10.1016/S0031-9422(00)89324-3. 

[edit] External links

The CAS registry number for this enzyme class is 59125-53-0.

• IUBMB entry for 5.4.3.7

• KEGG entry for 5.4.3.7

• BRENDA entry for 5.4.3.7

• NiceZyme view of 5.4.3.7

• EC2PDB: PDB structures for 5.4.3.7

• PRIAM entry for 5.4.3.7

• PUMA2 entry for 5.4.3.7

• IntEnz: Integrated Enzyme entry for 5.4.3.7

• MetaCyc entry for 5.4.3.7

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050047: leucine 2,3-aminomutase

• AMIGO entry for GO code 0050047: leucine 2,3-aminomutase