Talk:Leigh's disease
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[edit] Re
Re: Below note on inheritance. Leigh's Disease can be inherited via the mitochondrial DNA (mtDNA), Nuclear DNA, or it can be X-Linked. There are documented cases of all 3 inheritance patterns.
[edit] Inheritance
I am almost 100% sure that the cause underlying Leigh`s disease is not a mutation in the mDNA (I also think this must be mtDNA) but that the defect is nuclear encoded. In this case it is autosomal or x-linked recessive inherited.
There are a few types of Leigh's disease. What you're referring to is the X linked Leigh's disease which is not a mutation in the Oxidative Phosphorylation enzymes (which are both on the mtDNA and the nuclear DNA). The X-linked Leigh's disease is a mutation of the gene encoding the E1-alpha subunit of the pyruvate dehydrogenase complex, which is located on the X chomosome. More information on this can be found at OMIM.--Nate 18:54, 18 September 2006 (UTC)
[edit] WikiProject class rating
This article was automatically assessed because at least one WikiProject had rated the article as start, and the rating on other projects was brought up to start class. BetacommandBot 16:28, 10 November 2007 (UTC)
[edit] Info on Dr. Marie Sanzalone
Hi, just curious if anybody else thinks that the information about Dr. Sanzalone should be removed from this page about "Leigh's disease" and moved to a separate biographical article about her, which doesn't exist at this point as far as I can tell. thanks. —Preceding unsigned comment added by Fythrion (talk • contribs) 20:13, 3 March 2008 (UTC) I've removed it because it was unsourced. Filip en (talk) 23:02, 30 March 2008 (UTC)