Talk:Leigh's disease

From Wikipedia, the free encyclopedia

WikiProject Neurology This article is within the scope of WikiProject Neurology. Please visit the project page for details or ask questions at the talk page.
Start This page has been rated as Start-Class on the quality assessment scale
Mid This article has been rated as Mid-importance on the importance assessment scale
WikiProject Genetics This article is part of WikiProject Genetics, an attempt to build a comprehensive and detailed guide to genetics on Wikipedia. If you would like to participate, you can edit this page, or visit the project page to join the project and/or contribute to the discussion.
??? This article has not yet received a rating on the quality scale.
??? This article has not yet received an importance rating.
WikiProject Medicine This article is within the scope of WikiProject Medicine. Please visit the project page for details or ask questions at the doctor's mess.
Start This page has been rated as Start-Class on the quality assessment scale
Low This article has been rated as Low-importance on the importance assessment scale
WikiProject on Medical genetics This article is supported by the WikiProject on Medical Genetics, which gives a central approach to Medical genetics and related subjects on Wikipedia. Please participate by editing the article Leigh's disease, or visit the project page for more details on the projects.
Start This article has been rated as Start-Class on the quality scale.

Contents

[edit] Re

Re: Below note on inheritance. Leigh's Disease can be inherited via the mitochondrial DNA (mtDNA), Nuclear DNA, or it can be X-Linked. There are documented cases of all 3 inheritance patterns.

[edit] Inheritance

I am almost 100% sure that the cause underlying Leigh`s disease is not a mutation in the mDNA (I also think this must be mtDNA) but that the defect is nuclear encoded. In this case it is autosomal or x-linked recessive inherited.


There are a few types of Leigh's disease. What you're referring to is the X linked Leigh's disease which is not a mutation in the Oxidative Phosphorylation enzymes (which are both on the mtDNA and the nuclear DNA). The X-linked Leigh's disease is a mutation of the gene encoding the E1-alpha subunit of the pyruvate dehydrogenase complex, which is located on the X chomosome. More information on this can be found at OMIM.--Nate 18:54, 18 September 2006 (UTC)

[edit] WikiProject class rating

This article was automatically assessed because at least one WikiProject had rated the article as start, and the rating on other projects was brought up to start class. BetacommandBot 16:28, 10 November 2007 (UTC)

[edit] Info on Dr. Marie Sanzalone

Hi, just curious if anybody else thinks that the information about Dr. Sanzalone should be removed from this page about "Leigh's disease" and moved to a separate biographical article about her, which doesn't exist at this point as far as I can tell. thanks. —Preceding unsigned comment added by Fythrion (talkcontribs) 20:13, 3 March 2008 (UTC) I've removed it because it was unsourced. Filip en (talk) 23:02, 30 March 2008 (UTC)