LECT2

From Wikipedia, the free encyclopedia

Leukocyte cell-derived chemotaxin 2

Identifiers

LECT2; MGC126628; chm-II; chm2

External IDs

OMIM: 602882 MGI: 1278342 HomoloGene: 1730

Gene ontology
Molecular Function:	• metalloendopeptidase activity
Cellular Component:	• extracellular space • cytoplasm
Biological Process:	• skeletal development • proteolysis • chemotaxis

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_002302 (mRNA)
NP_002293 (protein)

NM_010702 (mRNA)
NP_034832 (protein)

Location

Chr 5: 135.31 - 135.32 Mb

Chr 13: 56.55 - 56.56 Mb

Pubmed search

[1]

[2]

Leukocyte cell-derived chemotaxin 2, also known as LECT2, is a human gene.^[1]

This gene encodes a secreted, 16 kDa protein that acts as a chemotactic factor to neutrophils and stimulates the growth of chondrocytes and osteoblasts. This protein has high sequence similarity to the chondromodulin repeat regions of the chicken myb-induced myeloid 1 protein. A polymorphism in this gene may be associated with rheumatoid arthritis.^[1]

[edit] References

^ ^a ^b Entrez Gene: LECT2 leukocyte cell-derived chemotaxin 2.

[edit] Further reading

Yamagoe S, Yamakawa Y, Matsuo Y, et al. (1997). "Purification and primary amino acid sequence of a novel neutrophil chemotactic factor LECT2.". Immunol. Lett. 52 (1): 9–13. PMID 8877413.
Yamagoe S, Akasaka T, Uchida T, et al. (1997). "Expression of a neutrophil chemotactic protein LECT2 in human hepatocytes revealed by immunochemical studies using polyclonal and monoclonal antibodies to a recombinant LECT2.". Biochem. Biophys. Res. Commun. 237 (1): 116–20. doi:10.1006/bbrc.1997.7095. PMID 9266841.
Yamagoe S, Mizuno S, Suzuki K (1998). "Molecular cloning of human and bovine LECT2 having a neutrophil chemotactic activity and its specific expression in the liver.". Biochim. Biophys. Acta 1396 (1): 105–13. PMID 9524238.
Yamagoe S, Kameoka Y, Hashimoto K, et al. (1998). "Molecular cloning, structural characterization, and chromosomal mapping of the human LECT2 gene.". Genomics 48 (3): 324–9. doi:10.1006/geno.1997.5198. PMID 9545637.
Nagai H, Hamada T, Uchida T, et al. (1999). "Systemic expression of a newly recognized protein, LECT2, in the human body.". Pathol. Int. 48 (11): 882–6. PMID 9832057.
Kameoka Y, Yamagoe S, Hatano Y, et al. (2000). "Val58Ile polymorphism of the neutrophil chemoattractant LECT2 and rheumatoid arthritis in the Japanese population.". Arthritis Rheum. 43 (6): 1419–20. doi:10.1002/1529-0131(200006)43:6<1419::AID-ANR28>3.0.CO;2-I. PMID 10857804.
Xu XR, Huang J, Xu ZG, et al. (2002). "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver.". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 15089–94. doi:10.1073/pnas.241522398. PMID 11752456.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ovejero C, Cavard C, Périanin A, et al. (2004). "Identification of the leukocyte cell-derived chemotaxin 2 as a direct target gene of beta-catenin in the liver.". Hepatology 40 (1): 167–76. doi:10.1002/hep.20286. PMID 15239100.
Ito M, Nagata K, Yumoto F, et al. (2005). "1H, 13C, 15N resonance assignments of the cytokine LECT2.". J. Biomol. NMR 29 (4): 543–4. doi:10.1023/B:JNMR.0000034343.48628.f6. PMID 15243190.
Schmutz J, Martin J, Terry A, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 5.". Nature 431 (7006): 268–74. doi:10.1038/nature02919. PMID 15372022.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Sato Y, Watanabe H, Kameyama H, et al. (2005). "Changes in serum LECT 2 levels during the early period of liver regeneration after adult living related donor liver transplantation.". Transplant. Proc. 36 (8): 2357–8. doi:10.1016/j.transproceed.2004.07.006. PMID 15561248.
Sato Y, Watanabe H, Kameyama H, et al. (2005). "Serum LECT2 level as a prognostic indicator in acute liver failure.". Transplant. Proc. 36 (8): 2359–61. doi:10.1016/j.transproceed.2004.07.007. PMID 15561249.