LECT1

From Wikipedia, the free encyclopedia

Leukocyte cell derived chemotaxin 1

Identifiers

LECT1; BRICD3; CHM-I; CHM1

External IDs

OMIM: 605147 MGI: 1341171 HomoloGene: 5095

Gene ontology
Cellular Component:	• basement membrane • extracellular space • membrane • integral to membrane
Biological Process:	• proteoglycan metabolic process • multicellular organismal development • cell differentiation • cartilage development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001011705 (mRNA)
NP_001011705 (protein)

NM_010701 (mRNA)
NP_034831 (protein)

Location

Chr 13: 52.18 - 52.21 Mb

Chr 14: 78.37 - 78.4 Mb

Pubmed search

[1]

[2]

Leukocyte cell derived chemotaxin 1, also known as LECT1, is a human gene.^[1]

This gene encodes a glycosylated transmembrane protein that is cleaved to form a mature, secreted protein. The N-terminus of the precursor protein shares characteristics with other surfactant proteins and is sometimes called chondrosurfactant protein although no biological activity has yet been defined for it. The C-terminus of the precursor protein contains a 25 kDa mature protein called leukocyte cell-derived chemotaxin-1 or chondromodulin-1. The mature protein promotes chondrocyte growth and inhibits angiogenesis. This gene is expressed in the avascular zone of prehypertrophic cartilage and its expression decreases during chondrocyte hypertrophy and vascular invasion. The mature protein likely plays a role in endochondral bone development by permitting cartilaginous anlagen to be vascularized and replaced by bone. It may be involved also in the broad control of tissue vascularization during development. Alternative splicing results in multiple transcript variants encoding different isoforms.^[1]

[edit] References

^ ^a ^b Entrez Gene: LECT1 leukocyte cell derived chemotaxin 1.

[edit] Further reading

Hiraki Y, Shukunami C (2000). "Chondromodulin-I as a novel cartilage-specific growth-modulating factor.". Pediatr. Nephrol. 14 (7): 602-5. PMID 10912526.
Shukunami C, Hiraki Y (1998). "Expression of cartilage-specific functional matrix chondromodulin-I mRNA in rabbit growth plate chondrocytes and its responsiveness to growth stimuli in vitro.". Biochem. Biophys. Res. Commun. 249 (3): 885-90. doi:10.1006/bbrc.1998.9233. PMID 9731231.
Hiraki Y, Mitsui K, Endo N, et al. (1999). "Molecular cloning of human chondromodulin-I, a cartilage-derived growth modulating factor, and its expression in Chinese hamster ovary cells.". Eur. J. Biochem. 260 (3): 869-78. PMID 10103018.
Hayami T, Shukunami C, Mitsui K, et al. (2000). "Specific loss of chondromodulin-I gene expression in chondrosarcoma and the suppression of tumor angiogenesis and growth by its recombinant protein in vivo.". FEBS Lett. 458 (3): 436-40. PMID 10570955.
Yanagihara I, Yamagata M, Sakai N, et al. (2000). "Genomic organization of the human chondromodulin-1 gene containing a promoter region that confers the expression of reporter gene in chondrogenic ATDC5 cells.". J. Bone Miner. Res. 15 (3): 421-9. PMID 10750556.
Azizan A, Holaday N, Neame PJ (2001). "Post-translational processing of bovine chondromodulin-I.". J. Biol. Chem. 276 (26): 23632-8. doi:10.1074/jbc.M009967200. PMID 11323410.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Aoyama T, Okamoto T, Nagayama S, et al. (2004). "Expression of the chondromodulin-I gene in chondrosarcomas.". Cancer Lett. 204 (1): 61-8. PMID 14744535.
Aoyama T, Okamoto T, Nagayama S, et al. (2004). "Methylation in the core-promoter region of the chondromodulin-I gene determines the cell-specific expression by regulating the binding of transcriptional activator Sp3.". J. Biol. Chem. 279 (27): 28789-97. doi:10.1074/jbc.M401273200. PMID 15107420.
Yoshioka M, Yuasa S, Matsumura K, et al. (2006). "Chondromodulin-I maintains cardiac valvular function by preventing angiogenesis.". Nat. Med. 12 (10): 1151-9. doi:10.1038/nm1476. PMID 16980969.