Talk:Leber's hereditary optic neuropathy

From Wikipedia, the free encyclopedia

	This article is part of WikiProject Genetics, an attempt to build a comprehensive and detailed guide to genetics on Wikipedia. If you would like to participate, you can edit this page, or visit the project page to join the project and/or contribute to the discussion.
???	This article has not yet received a rating on the quality scale.
???	This article has not yet received an importance rating.

	This article is supported by the WikiProject on Medical Genetics, which gives a central approach to Medical genetics and related subjects on Wikipedia. Please participate by editing the article Leber's hereditary optic neuropathy, or visit the project page for more details on the projects.
Start	This article has been rated as Start-Class on the quality scale.

This is the talk page for discussing improvements to the Leber's hereditary optic neuropathy article.
Please sign and date your posts by typing four tildes (~~~~). Put new text under old text. Click here to start a new topic. New to Wikipedia? Welcome! Ask questions, get answers. This is not a forum for general discussion about the article's subject.	Be polite Assume good faith No personal attacks Be welcoming	Article policies No original research Neutral point of view Verifiability

	This article is within the scope of WikiProject Medicine. Please visit the project page for details or ask questions at the doctor's mess.
Start	This page has been rated as Start-Class on the quality assessment scale
Mid	This article has been rated as Mid-importance on the importance assessment scale

Contents 1 Introductory sentence 2 vandalism 3 contradiction in opening paragraph 4 Removed reference to paternal inheritance of mtDNA 5 Citation for edit

[edit] Introductory sentence

The opening sentence states: Leber’s hereditary optic neuropathy (LHON) or Leber optic atrophy is a maternally inherited form of acute or subacute loss of central vision that may lead to degeneration of retinal ganglion cells (RGCs) and their axons... Degeneration leads to vision loss, not the other way around. Anyone agree that this should be changed? AED 06:30, 28 July 2005 (UTC)

[edit] vandalism

I removed the section regarding clinical trials in the UK. It may be relevant to the article, but it's still advertising. This user has been told numerous times about vandalism, so see the users page or their other page. If anyone has a good reason to revert it, then revert it. Jay.S 22:12, 14 February 2007 (UTC)

[edit] contradiction in opening paragraph

the part in brackets about 1 in 100000 men passing on mitchondria means that a man could pass on this disease to his offspring it would just be extremely unlikely. Sorry to be such a pedant. Greatunknown1 00:27, 15 November 2007 (UTC)

[edit] Removed reference to paternal inheritance of mtDNA

Paternal inheritance has never been proven to take place in humans. The latest studies have been unable to find a single case, even among those that in the past were thought to have been candidates for this.
Telling people that mitochondrial diseases are sometimes paternally inherited is in this case not just some sort of obscure scientific controversy, but is actually damaging to people who are trying to learn about these diseases. What about a man who has such a condition who reads this, and then is worried that he might pass it on to his children? What if he decides not to have children, or get a vasectomy, based on what he read here?
Archaeogenetics (talk) 01:00, 14 February 2008 (UTC)

[edit] Citation for edit

I added age of onset to Signs and Sx. Here is the citation. The clinical characteristics of pedigrees of Leber's hereditary optic neuropathy with the 11778 mutation.

Newman NJ; Lott MT; Wallace DC  
Am J Ophthalmol 1991 Jun 15;111(6):750-62.  —Preceding unsigned comment added by 204.86.231.10 (talk) 14:37, 4 June 2008 (UTC)