LDOC1

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Leucine zipper, down-regulated in cancer 1
Identifiers
Symbol(s) LDOC1; BCUR1; Mar7; Mart7
External IDs OMIM: 300402 MGI: 2685212 HomoloGene: 32153
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 23641 434784
Ensembl ENSG00000182195 ENSMUSG00000057615
Uniprot O95751 Q7TPY9
Refseq NM_012317 (mRNA)
NP_036449 (protein)		 NM_001018087 (mRNA)
NP_001018097 (protein)
Location Chr X: 140.1 - 140.1 Mb Chr X: 57.97 - 57.97 Mb
Pubmed search [1] [2]

Leucine zipper, down-regulated in cancer 1, also known as LDOC1, is a human gene.[1]

The protein encoded by this gene contains a leucine zipper-like motif and a proline-rich region that shares marked similarity with an SH3-binding domain. The protein localizes to the nucleus and is down-regulated in some cancer cell lines. It is thought to regulate the transcriptional response mediated by the nuclear factor kappa B (NF-kappaB). The gene has been proposed as a tumor suppressor gene whose protein product may have an important role in the development and/or progression of some cancers.[1]

[edit] References

  1. ^ a b Entrez Gene: LDOC1 leucine zipper, down-regulated in cancer 1.

[edit] Further reading

  • Nagasaki K, Manabe T, Hanzawa H, et al. (1999). "Identification of a novel gene, LDOC1, down-regulated in cancer cell lines.". Cancer Lett. 140 (1-2): 227–34. PMID 10403563. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Nagasaki K, Schem C, von Kaisenberg C, et al. (2003). "Leucine-zipper protein, LDOC1, inhibits NF-kappaB activation and sensitizes pancreatic cancer cells to apoptosis.". Int. J. Cancer 105 (4): 454–8. doi:10.1002/ijc.11122. PMID 12712434. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Chih DY, Park DJ, Gross M, et al. (2005). "Protein partners of C/EBPepsilon.". Exp. Hematol. 32 (12): 1173–81. doi:10.1016/j.exphem.2004.08.014. PMID 15588942. 
  • Inoue M, Takahashi K, Niide O, et al. (2005). "LDOC1, a novel MZF-1-interacting protein, induces apoptosis.". FEBS Lett. 579 (3): 604–8. doi:10.1016/j.febslet.2004.12.030. PMID 15670815. 
  • Brandt J, Schrauth S, Veith AM, et al. (2005). "Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals.". Gene 345 (1): 101–11. doi:10.1016/j.gene.2004.11.022. PMID 15716091. 
  • Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMID 15772651. 
  • Brandt J, Veith AM, Volff JN (2005). "A family of neofunctionalized Ty3/gypsy retrotransposon genes in mammalian genomes.". Cytogenet. Genome Res. 110 (1-4): 307–17. doi:10.1159/000084963. PMID 16093683. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
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