LDB1

From Wikipedia, the free encyclopedia

LIM domain binding 1

Identifiers

LDB1; CLIM2; NLI

External IDs

OMIM: 603451 MGI: 894762 HomoloGene: 2891

Gene ontology
Molecular Function:	• transcription cofactor activity • transcription corepressor activity • LIM domain binding
Cellular Component:	• nucleus
Biological Process:	• multicellular organismal development • anterior/posterior axis specification • gastrulation (sensu Mammalia) • Wnt receptor signaling pathway • negative regulation of transcription, DNA-dependent

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003893 (mRNA)
NP_003884 (protein)

XM_980630 (mRNA)
XP_985724 (protein)

Location

Chr 10: 103.86 - 103.86 Mb

Chr 19: 46.09 - 46.1 Mb

Pubmed search

[1]

[2]

LIM domain binding 1, also known as LDB1, is a human gene.^[1]

[edit] References

^ Entrez Gene: LDB1 LIM domain binding 1.

[edit] Further reading

Osada H, Grutz GG, Axelson H, et al. (1997). "LIM-only protein Lmo2 forms a protein complex with erythroid transcription factor GATA-1.". Leukemia 11 Suppl 3: 307–12. PMID 9209374.
Wadman IA, Osada H, Grütz GG, et al. (1997). "The LIM-only protein Lmo2 is a bridging molecule assembling an erythroid, DNA-binding complex which includes the TAL1, E47, GATA-1 and Ldb1/NLI proteins.". EMBO J. 16 (11): 3145–57. doi:10.1093/emboj/16.11.3145. PMID 9214632.
Jurata LW, Gill GN (1997). "Functional analysis of the nuclear LIM domain interactor NLI.". Mol. Cell. Biol. 17 (10): 5688–98. PMID 9315627.
Visvader JE, Mao X, Fujiwara Y, et al. (1998). "The LIM-domain binding protein Ldb1 and its partner LMO2 act as negative regulators of erythroid differentiation.". Proc. Natl. Acad. Sci. U.S.A. 94 (25): 13707–12. PMID 9391090.
Jurata LW, Pfaff SL, Gill GN (1998). "The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors.". J. Biol. Chem. 273 (6): 3152–7. PMID 9452425.
Yamashita T, Agulnick AD, Copeland NG, et al. (1998). "Genomic structure and chromosomal localization of the mouse LIM domain-binding protein 1 gene, Ldb1.". Genomics 48 (1): 87–92. doi:10.1006/geno.1997.5163. PMID 9503020.
Kenny DA, Jurata LW, Saga Y, Gill GN (1998). "Identification and characterization of LMO4, an LMO gene with a novel pattern of expression during embryogenesis.". Proc. Natl. Acad. Sci. U.S.A. 95 (19): 11257–62. PMID 9736723.
Semina EV, Altherr MR, Murray JC (1998). "Cloning and chromosomal localization of two novel human genes encoding LIM-domain binding factors CLIM1 and CLIM2/LDB1/NLI.". Mamm. Genome 9 (11): 921–4. PMID 9799849.
Valge-Archer V, Forster A, Rabbitts TH (1999). "The LMO1 and LDB1 proteins interact in human T cell acute leukaemia with the chromosomal translocation t(11;14)(p15;q11).". Oncogene 17 (24): 3199–202. doi:10.1038/sj.onc.1202353. PMID 9872335.
Ueki N, Seki N, Yano K, et al. (1999). "Isolation and chromosomal assignment of human genes encoding cofactor of LIM homeodomain proteins, CLIM1 and CLIM2.". J. Hum. Genet. 44 (2): 112–5. PMID 10083735.
Drechsler M, Schumacher V, Friedrich S, et al. (2000). "Genomic structure, alternative transcripts and chromosome location of the human LIM domain binding protein 1 gene LDB1.". Cytogenet. Cell Genet. 87 (1-2): 119–24. PMID 10640831.
Dreyer SD, Morello R, German MS, et al. (2000). "LMX1B transactivation and expression in nail-patella syndrome.". Hum. Mol. Genet. 9 (7): 1067–74. PMID 10767331.
Sum EY, Peng B, Yu X, et al. (2002). "The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity.". J. Biol. Chem. 277 (10): 7849–56. doi:10.1074/jbc.M110603200. PMID 11751867.
Ostendorff HP, Peirano RI, Peters MA, et al. (2002). "Ubiquitination-dependent cofactor exchange on LIM homeodomain transcription factors.". Nature 416 (6876): 99–103. doi:10.1038/416099a. PMID 11882901.
Deane JE, Visvader JE, Mackay JP, Matthew JM (2003). "1H, 15N and 13C assignments of FLIN4, an intramolecular LMO4:ldb1 complex.". J. Biomol. NMR 23 (2): 165–6. PMID 12153047.
Chen L, Segal D, Hukriede NA, et al. (2002). "Ssdp proteins interact with the LIM-domain-binding protein Ldb1 to regulate development.". Proc. Natl. Acad. Sci. U.S.A. 99 (22): 14320–5. doi:10.1073/pnas.212532399. PMID 12381786.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
van Meyel DJ, Thomas JB, Agulnick AD (2003). "Ssdp proteins bind to LIM-interacting co-factors and regulate the activity of LIM-homeodomain protein complexes in vivo.". Development 130 (9): 1915–25. PMID 12642495.
Deane JE, Mackay JP, Kwan AH, et al. (2003). "Structural basis for the recognition of ldb1 by the N-terminal LIM domains of LMO2 and LMO4.". EMBO J. 22 (9): 2224–33. doi:10.1093/emboj/cdg196. PMID 12727888.
Marini M, Bongers EM, Cusano R, et al. (2004). "Confirmation of CLIM2/LMX1B interaction by yeast two-hybrid screening and analysis of its involvement in nail-patella syndrome.". Int. J. Mol. Med. 12 (1): 79–82. PMID 12792813.