LCOR

From Wikipedia, the free encyclopedia

Ligand dependent nuclear receptor corepressor

PDB rendering based on 2cob.

Available structures: 2cob

Identifiers

Symbol(s)

LCOR; FLJ38026; KIAA1795; MLR2; RP11-175O19.1

External IDs

OMIM: 607698 MGI: 2443930 HomoloGene: 18153

Gene ontology
Molecular Function:	• DNA binding
Cellular Component:	• nucleus
Biological Process:	• transcription • regulation of transcription, DNA-dependent

Orthologs

Human

Mouse

Refseq

NM_032440 (mRNA)
NP_115816 (protein)

NM_172154 (mRNA)
NP_742166 (protein)

Location

Chr 10: 98.58 - 98.71 Mb

Chr 19: 41.58 - 41.62 Mb

Pubmed search

[1]

[2]

Ligand dependent nuclear receptor corepressor, also known as LCOR, is a human gene.^[1]

LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: LCOR ligand dependent nuclear receptor corepressor.

[edit] Further reading

White JH, Fernandes I, Mader S, Yang XJ (2004). "Corepressor recruitment by agonist-bound nuclear receptors.". Vitam. Horm. 68: 123–43. doi:10.1016/S0083-6729(04)68004-6. PMID 15193453.
Nagase T, Nakayama M, Nakajima D, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 8 (2): 85–95. PMID 11347906.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Fernandes I, Bastien Y, Wai T, et al. (2003). "Ligand-dependent nuclear receptor corepressor LCoR functions by histone deacetylase-dependent and -independent mechanisms.". Mol. Cell 11 (1): 139–50. PMID 12535528.
Kunieda T, Park JM, Takeuchi H, Kubo T (2003). "Identification and characterization of Mlr1,2: two mouse homologues of Mblk-1, a transcription factor from the honeybee brain(1).". FEBS Lett. 535 (1-3): 61–5. PMID 12560079.
Shi Y, Sawada J, Sui G, et al. (2003). "Coordinated histone modifications mediated by a CtBP co-repressor complex.". Nature 422 (6933): 735–8. doi:10.1038/nature01550. PMID 12700765.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375–81. doi:10.1038/nature02462. PMID 15164054.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.