LCMT2

From Wikipedia, the free encyclopedia


Leucine carboxyl methyltransferase 2
Identifiers
Symbol(s) LCMT2; KIAA0547; MGC9534; PPM2; TYW4
External IDs MGI: 1353659 HomoloGene: 19642
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 9836 329504
Ensembl ENSG00000168806 ENSMUSG00000074890
Uniprot O60294 Q8BYR1
Refseq NM_014793 (mRNA)
NP_055608 (protein)		 XM_001003239 (mRNA)
XP_001003239 (protein)
Location Chr 15: 41.41 - 41.41 Mb Chr 2: 120.83 - 120.83 Mb
Pubmed search [1] [2]

Leucine carboxyl methyltransferase 2, also known as LCMT2, is a human gene.[1]

The protein encoded by this intronless gene belongs to the methyltransferase superfamily and acts as a G(1)/S and G(2)/M phase checkpoint regulator. It has been hypothesized that cigarette smoke-induced oxidative stress and transforming growth factor beta 1 may inhibit cellular proliferation by modulating the expression of this protein.[1]

[edit] References

  1. ^ a b Entrez Gene: LCMT2 leucine carboxyl methyltransferase 2.

[edit] Further reading

  • Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (1): 31–9. PMID 9628581. 
  • De Baere I, Derua R, Janssens V, et al. (2000). "Purification of porcine brain protein phosphatase 2A leucine carboxyl methyltransferase and cloning of the human homologue.". Biochemistry 38 (50): 16539–47. PMID 10600115. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Marwick JA, Kirkham P, Gilmour PS, et al. (2003). "Cigarette smoke-induced oxidative stress and TGF-beta1 increase p21waf1/cip1 expression in alveolar epithelial cells.". Ann. N. Y. Acad. Sci. 973: 278–83. PMID 12485877. 
  • Ng CC, Arakawa H, Fukuda S, et al. (2003). "p53RFP, a p53-inducible RING-finger protein, regulates the stability of p21WAF1.". Oncogene 22 (28): 4449–58. doi:10.1038/sj.onc.1206586. PMID 12853982. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Kawamata N, Inagaki N, Mizumura S, et al. (2005). "Methylation status analysis of cell cycle regulatory genes (p16INK4A, p15INK4B, p21Waf1/Cip1, p27Kip1 and p73) in natural killer cell disorders.". Eur. J. Haematol. 74 (5): 424–9. doi:10.1111/j.1600-0609.2005.00417.x. PMID 15813917. 
  • Noma A, Kirino Y, Ikeuchi Y, Suzuki T (2006). "Biosynthesis of wybutosine, a hyper-modified nucleoside in eukaryotic phenylalanine tRNA.". EMBO J. 25 (10): 2142–54. doi:10.1038/sj.emboj.7601105. PMID 16642040. 
  • Liu FY, Qi JP, Xu FL, Wu AP (2006). "Clinicopathological and immunohistochemical analysis of gastrointestinal stromal tumor.". World J. Gastroenterol. 12 (26): 4161–5. PMID 16830365. 
  • Moon SK, Choi YH, Kim CH, Choi WS (2006). "p38MAPK mediates benzyl isothiocyanate-induced p21WAF1 expression in vascular smooth muscle cells via the regulation of Sp1.". Biochem. Biophys. Res. Commun. 350 (3): 662–8. doi:10.1016/j.bbrc.2006.09.092. PMID 17026958. 
 This article on a gene on chromosome 15 is a stub. You can help Wikipedia by expanding it.