LBX1

From Wikipedia, the free encyclopedia

Ladybird homeobox 1

Identifiers

LBX1; HPX-6; LBX1H; homeobox

External IDs

OMIM: 604255 MGI: 104867 HomoloGene: 4784

Gene ontology
Molecular Function:	• transcription factor activity • protein binding • sequence-specific DNA binding
Cellular Component:	• nucleus • transcription factor complex
Biological Process:	• heart looping • regulation of transcription, DNA-dependent • multicellular organismal development • nervous system development • striated muscle development • negative regulation of cell proliferation • anatomical structure morphogenesis • cell differentiation • negative regulation of neuron differentiation • neuron fate determination

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006562 (mRNA)
NP_006553 (protein)

NM_010691 (mRNA)
NP_034821 (protein)

Location

Chr 10: 102.98 - 102.98 Mb

Chr 19: 45.29 - 45.29 Mb

Pubmed search

[1]

[2]

Ladybird homeobox 1, also known as LBX1, is a human gene.^[1]

This gene and the orthologous mouse gene were found by their homology to the Drosophila lady bird early and late homeobox genes. In the mouse, this gene is a key regulator of muscle precursor cell migration and is required for the acquisition of dorsal identities of forelimb muscles.^[1]

[edit] References

^ ^a ^b Entrez Gene: LBX1 ladybird homeobox 1.

[edit] Further reading

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10.". Nature 429 (6990): 375-81. doi:10.1038/nature02462. PMID 15164054.
de Mollerat XJ, Gurrieri F, Morgan CT, et al. (2004). "A genomic rearrangement resulting in a tandem duplication is associated with split hand-split foot malformation 3 (SHFM3) at 10q24.". Hum. Mol. Genet. 12 (16): 1959-71. PMID 12913067.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Kozmik Z, Holland LZ, Schubert M, et al. (2001). "Characterization of Amphioxus AmphiVent, an evolutionarily conserved marker for chordate ventral mesoderm.". Genesis 29 (4): 172-9. PMID 11309850.
Jagla K, Dollé P, Mattei MG, et al. (1996). "Mouse Lbx1 and human LBX1 define a novel mammalian homeobox gene family related to the Drosophila lady bird genes.". Mech. Dev. 53 (3): 345-56. PMID 8645601.
Moretti P, Simmons P, Thomas P, et al. (1994). "Identification of homeobox genes expressed in human haemopoietic progenitor cells.". Gene 144 (2): 213-9. PMID 7518789.