Latanoprost

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Latanoprost
Systematic (IUPAC) name
isopropyl (Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2- [(3R)3-hydroxy-5-phenylpentyl]-cyclopentyl] hept-5-enoate
Identifiers
CAS number 130209-82-4
ATC code S01EE01
PubChem 60798
DrugBank APRD01065
Chemical data
Formula C26H40O5 
Mol. mass 432.593 g/mol
SMILES eMolecules & PubChem
Pharmacokinetic data
Bioavailability  ?
Metabolism  ?
Half life 17 minutes
Excretion  ?
Therapeutic considerations
Pregnancy cat.

?

Legal status
Routes Topical (eye drops)

Latanoprost (pronounced la-TA-noe-prost) ophthalmic solution is a topical medication used for controlling the progression of glaucoma or ocular hypertension, by reducing intraocular pressure. It is a prostaglandin analogue that works by increasing the outflow of aqueous fluid from the eyes.

It is also known by the brand name of Xalatan manufactured by Pfizer.

[edit] Side effects

Possible side effects:

  • May cause reddening of the eyes (hyperemia)
  • May cause blurred vision;
  • May cause eyelid redness;
  • May permanently darken eyelashes;
  • May cause eye discomfort;
  • May eventually cause permanent darkening of the iris to brown (heterochromia);
  • May cause a temporary burning sensation during use.
  • May cause thickening of the eyelashes.
  • Rarely, herpes simplex keratitis.

[edit] External links

  • Xalatan (manufacturer's website)
  • Hara T (2001). "Increased iris pigmentation after use of latanoprost in Japanese brown eyes". Nippon Ganka Gakkai Zasshi 105 (5): 314–21. PMID 11406947. 



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