Laminin, alpha 2

From Wikipedia, the free encyclopedia

Laminin, alpha 2 (merosin, congenital muscular dystrophy)

Identifiers

External IDs

OMIM: 156225 MGI: 99912 HomoloGene: 37306

Gene ontology
Molecular Function:	• receptor binding • structural molecule activity
Cellular Component:	• basement membrane • laminin-1 complex • extracellular matrix
Biological Process:	• muscle development • regulation of cell adhesion • regulation of cell migration • regulation of embryonic development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_000426 (mRNA)
NP_000417 (protein)

NM_008481 (mRNA)
NP_032507 (protein)

Location

Chr 6: 129.25 - 129.88 Mb

Chr 10: 26.67 - 27.31 Mb

Pubmed search

[1]

[2]

Laminin, alpha 2 (merosin, congenital muscular dystrophy), also known as LAMA2, is a human gene.^[1]

Laminin, an extracellular protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene.^[1]

[edit] References

^ ^a ^b Entrez Gene: LAMA2 laminin, alpha 2 (merosin, congenital muscular dystrophy).

[edit] Further reading

Timpl R (1997). "Macromolecular organization of basement membranes.". Curr. Opin. Cell Biol. 8 (5): 618–24. PMID 8939648.
Belkin AM, Stepp MA (2000). "Integrins as receptors for laminins.". Microsc. Res. Tech. 51 (3): 280–301. doi:10.1002/1097-0029(20001101)51:3<280::AID-JEMT7>3.0.CO;2-O. PMID 11054877.
Jones KJ, Morgan G, Johnston H, et al. (2002). "The expanding phenotype of laminin alpha2 chain (merosin) abnormalities: case series and review.". J. Med. Genet. 38 (10): 649–57. PMID 11584042.
Ehrig K, Leivo I, Argraves WS, et al. (1990). "Merosin, a tissue-specific basement membrane protein, is a laminin-like protein.". Proc. Natl. Acad. Sci. U.S.A. 87 (9): 3264–8. PMID 2185464.
Hori H, Kanamori T, Mizuta T, et al. (1995). "Human laminin M chain: epitope analysis of its monoclonal antibodies by immunoscreening of cDNA clones and tissue expression.". J. Biochem. 116 (6): 1212–9. PMID 7535762.
Helbling-Leclerc A, Zhang X, Topaloglu H, et al. (1995). "Mutations in the laminin alpha 2-chain gene (LAMA2) cause merosin-deficient congenital muscular dystrophy.". Nat. Genet. 11 (2): 216–8. doi:10.1038/ng1095-216. PMID 7550355.
Yamada H, Shimizu T, Tanaka T, et al. (1994). "Dystroglycan is a binding protein of laminin and merosin in peripheral nerve.". FEBS Lett. 352 (1): 49–53. PMID 7925941.
Vuolteenaho R, Nissinen M, Sainio K, et al. (1994). "Human laminin M chain (merosin): complete primary structure, chromosomal assignment, and expression of the M and A chain in human fetal tissues.". J. Cell Biol. 124 (3): 381–94. PMID 8294519.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Zhang X, Vuolteenaho R, Tryggvason K (1996). "Structure of the human laminin alpha2-chain gene (LAMA2), which is affected in congenital muscular dystrophy.". J. Biol. Chem. 271 (44): 27664–9. PMID 8910357.
Squarzoni S, Villanova M, Sabatelli P, et al. (1997). "Intracellular detection of laminin alpha 2 chain in skin by electron microscopy immunocytochemistry: comparison between normal and laminin alpha 2 chain deficient subjects.". Neuromuscul. Disord. 7 (2): 91–8. PMID 9131649.
Allamand V, Sunada Y, Salih MA, et al. (1997). "Mild congenital muscular dystrophy in two patients with an internally deleted laminin alpha2-chain.". Hum. Mol. Genet. 6 (5): 747–52. PMID 9158149.
Durkin ME, Loechel F, Mattei MG, et al. (1997). "Tissue-specific expression of the human laminin alpha5-chain, and mapping of the gene to human chromosome 20q13.2-13.3 and to distal mouse chromosome 2 near the locus for the ragged (Ra) mutation.". FEBS Lett. 411 (2-3): 296–300. PMID 9271224.
Mrowiec T, Melchar C, Górski A (1998). "HIV-protein-mediated alterations in T cell interactions with the extracellular matrix proteins and endothelium.". Arch. Immunol. Ther. Exp. (Warsz.) 45 (2-3): 255–9. PMID 9597096.
Koch M, Olson PF, Albus A, et al. (1999). "Characterization and expression of the laminin gamma3 chain: a novel, non-basement membrane-associated, laminin chain.". J. Cell Biol. 145 (3): 605–18. PMID 10225960.
Kuang W, Xu H, Vilquin JT, Engvall E (2000). "Activation of the lama2 gene in muscle regeneration: abortive regeneration in laminin alpha2-deficiency.". Lab. Invest. 79 (12): 1601–13. PMID 10616210.
Pegoraro E, Fanin M, Trevisan CP, et al. (2000). "A novel laminin alpha2 isoform in severe laminin alpha2 deficient congenital muscular dystrophy.". Neurology 55 (8): 1128–34. PMID 11071490.
McArthur CP, Wang Y, Heruth D, Gustafson S (2001). "Amplification of extracellular matrix and oncogenes in tat-transfected human salivary gland cell lines with expression of laminin, fibronectin, collagens I, III, IV, c-myc and p53.". Arch. Oral Biol. 46 (6): 545–55. PMID 11311202.