Lactoyl-CoA dehydratase

From Wikipedia, the free encyclopedia

In enzymology, a lactoyl-CoA dehydratase (EC 4.2.1.54) is an enzyme that catalyzes the chemical reaction

lactoyl-CoA acryloyl-CoA + H₂O

Hence, this enzyme has one substrate, lactoyl-CoA, and two products, acryloyl-CoA and H₂O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is lactoyl-CoA hydro-lyase (acryloyl-CoA-forming). Other names in common use include lactoyl coenzyme A dehydratase, lactyl-coenzyme A dehydrase, lactyl CoA dehydratase, acrylyl coenzyme A hydratase, and lactoyl-CoA hydro-lyase. This enzyme participates in propanoate metabolism and styrene degradation.

[edit] References

• IUBMB entry for 4.2.1.54
• BRENDA references for 4.2.1.54 (Recommended.)
• PubMed references for 4.2.1.54
• PubMed Central references for 4.2.1.54
• Google Scholar references for 4.2.1.54
• BALDWIN RL, WOOD WA, EMERY RS (1965). "LACTATE METABOLISM BY PEPTOSTREPTOCOCCUS ELSDENII: EVIDENCE FOR LACTYL COENZYME A DEHYDRASE". Biochim. Biophys. Acta. 97: 202–13. PMID 14292829. 

[edit] External links

The CAS registry number for this enzyme class is 9031-12-3.

• IUBMB entry for 4.2.1.54

• KEGG entry for 4.2.1.54

• BRENDA entry for 4.2.1.54

• NiceZyme view of 4.2.1.54

• EC2PDB: PDB structures for 4.2.1.54

• PRIAM entry for 4.2.1.54

• PUMA2 entry for 4.2.1.54

• IntEnz: Integrated Enzyme entry for 4.2.1.54

• MetaCyc entry for 4.2.1.54

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0018819: lactoyl-CoA dehydratase

• AMIGO entry for GO code 0018819: lactoyl-CoA dehydratase